振源胶囊治疗冠心病慢性心力衰竭伴焦虑抑郁状态病人临床疗效分析

Correlation of Arterial Elasticity with Blood Pressure and Serum Protein

目的观察振源胶囊治疗冠心病慢性心力衰竭伴焦虑抑郁状态病人的临床疗效。方法随机选择2014年1月—2014年12月于我院心内科收治的60例冠心病慢性心力衰竭伴焦虑抑郁状态病人,采用随机数字表法分为试验组(30例)和对照组(30例)。对照组予以常规西药治疗+心理干预,试验组在对照组治疗基础上加用振源胶囊,10d为1个疗程,观察3个疗程。治疗后比较两组病人心功能、中医症状、焦虑自评量表(SDS)、抑郁自评量表(SAS)。结果治疗后试验组病人心功能疗效、中医症状疗效均高于对照组,差异有统计学意义(P<0.05)。治疗后对照组SDS及SAS评分无明显改善,差异无统计学意义(P>0.05),试验组SDS及SAS评分比治疗前显著下降,差异有统计学意义(P<0.01),且治疗后试验组评分明显低于对照组,差异有统计学意义(P<0.01)。结论振源胶囊能明显提高冠心病慢性心力衰竭病人的临床疗效,改善病人的焦虑抑郁状态。

Objective To study the relationship among arterial elasticity and blood pressure,serum protein.Methods Three hundredsand four patients in the medical center of the Southern District of Guang’ anmen Hospital of China Academy of Chinese Medical Sci-ences in July 2014 were enrolled.Asking medical history, measuring height, weight, body mass index （ BMI） , blood pressure, bloodroutine and biochemical indicators, and applying Omron BP 203RPEⅢ arteriosclerosis Arterial elasticity detector to test their arterialelasticity of the crowd, according to brachial ankle pulse wave velocity（ baPWV）artery into normal group（ n =117） , mild sclerosisgroup （ n =112）and hardening group （ n =75） , clinical indicators were compared between the three groups.Results Compared tonormal group, systolic blood pressure （ SBP） in mild sclerosis group and sclerosis group were significantly different,respectively, thedifference was statistically significant （ P 〈0.01） .Compared to normal group, diastolic blood pressure （ DBP） mild sclerosis group andsclerosis group were significantly different, respectively, the difference was statistically significant （ P 〈0.01） .Compared to normalgroup, serum albumin（ ALB） in mild sclerosis group and sclerosis group were significantly different,respectively, the difference wasstatistically significant（ P 〈0.05） ; compared to normal group, serum globulin （ GLB） in mild arterial sclerosis and normal group groupwere significantly different, and the difference was statistically significant （ P 〈0.05） .Conclusion analysis showed that three groupsof age, SBP, DBP, GLB and baPWV was positively correlated while ALB and baPWV were negatively correlated.TP was no correlationwith baPWV.Conclusion Serum levels of ALB, GLB could be used to estimate the early arterial elasticity, and we should strengthenthe detection of arterial elasticity elderly, prevent the occurrence of atherosclerosis.