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冻干重组人脑利钠肽治疗急性心肌梗死并心力衰竭的疗效观察 被引量:10

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摘要 目的观察冻干重组人脑利钠肽对急性心肌梗死合并心力衰竭病人的临床疗效。方法选择2012年8月—2014年9月就诊于本院的急性心肌梗死并心力衰竭病人53例,随机分为对照组和治疗组。对照组予以常规治疗,治疗组在对照组基础上连续给予冻干重组人脑利钠肽(lrh-BNP),直至1周。比较两组病人的临床疗效,肌酸激酶(CK-MB)、肌钙蛋白I(TnI)等心肌酶水平变化,左室射血分数、左室舒张末期容积指数以及左室收缩末期容积指数等左心功能指标。结果治疗组治疗后CK-MB及TnI水平较对照组及治疗前显著降低,差异有统计学意义(P<0.05)。治疗组射血分数较对照组及治疗前显著提高(P<0.05),舒张末期容积指数以及收缩末期容积指数显著降低(P<0.05)。治疗组临床疗效显著高于对照组(P<0.05)。结论冻干重组人脑利钠肽可有效降低急性心肌梗死并心力衰竭病人心肌酶水平,改善左心功能,临床疗效显著。
作者 朱黎姝
出处 《中西医结合心脑血管病杂志》 2016年第12期1377-1379,共3页 Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
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参考文献10

  • 1Shibata T,Kawakami S,Noguchi T,et al .Prevalence,clinicalfeatures,and prognosis of acute myocardial infarction attributableto coronary artery embolism[J].Circulation,2015,132(4):241-250.
  • 2张雪松,任海舟,黄广勇,汤雪露,杨兰菊.血运重建对急性心肌梗死患者心脏胶原重构及左心功能的影响[J].疑难病杂志,2010,9(12):889-891. 被引量:4
  • 3Shroff GR.Acute Myocardial Infarction[J].Ann Intern Med,2015,163(2):152.
  • 4李晓岚,高景利,阚志生,王爱田.重型颅脑损伤患者血清肌钙蛋白I及心肌酶谱变化的意义[J].疑难病杂志,2008,7(5):269-271. 被引量:5
  • 5Sudoh T,Kangawa K,Minamino N,et al .A new natriuretic peptidein porcine brain[J].Nature,1988,332(6159):78-81.
  • 6Meune C,Wahbi K,Gobeaux C,et al .N terminal Pro brain natriureticpeptide is a reliable biomarker of reduced myocardialcontractility in patients with lamin A/C gene mutations[J]. Int JCardiol,2011,151(2):160-163.
  • 7Kilickesmez KO,Ozkan AA,Abaci O,et al .Serum N terminalbrain natriuretic peptide indicates exercise induced augmentationof pulmonary artery pressure in patients with mitral stenosis[J].Echocardiography,2011,28(1):8-14.
  • 8Tycinska AM,Sobkowicz B,Mroczko B,et al .The value of apelin36 and brain natriuretic peptide measurements in patients withfirst ST elevation myocardial infarction [J]. Clin Chim Acta,2010,411(23 24):2014-2018.
  • 9McIlroy DR,Wallace S, Roubos N. Brain natriuretic peptide(BNP)as a biomarker of myocardial ischemia reperfusion injuryin cardiac transplantation [J]. J Cardiothorac Vasc Anesth,2010,24(6):939-945.
  • 10重组人脑利钠肽治疗心力衰竭安全性和疗效的开放性随机对照多中心临床研究[J].中华心血管病杂志,2011,39(4):305-308. 被引量:162

二级参考文献29

  • 1王治瑜,唐振刚.重型颅脑损伤对心肌的影响[J].中国误诊学杂志,2006,6(3):481-482. 被引量:7
  • 2谢洪智,朱文玲.重组人脑利钠肽和硝酸甘油治疗急性失代偿性心力衰竭疗效和安全性的随机、开放、平行对照的多中心临床研究[J].中华心血管病杂志,2006,34(3):222-226. 被引量:228
  • 3中华医学会心血管病学分会 中华心血管病杂志编辑委员会.慢性心力衰竭诊断治疗建议.中华心血管病杂志,2007,35(12):1076-1095.
  • 4Penq QH,Zhou QC,Zenq S,et al.Evaluation of regional left ventricular longitudinal function in 151 normal fetuses using velocity vector imaging[J].Prenat Diagn,2009,29(12):1149-1155.
  • 5Kasner M,Westermann D,Steendijk P,et al.Utility of Doppler echocardiography and tissue Doppler imaging in the estimation of diastolic function in heart failure with normal ejection fraction:a comparative Doppler-conductance catheterization study[J].Circulation,2007,116(6):637-647.
  • 6Boersma E.Does time mater? A Pooled analysis of randomized clinical trials comparing primary percutaneous coronary intervention and in-hospital fibrinolysis in acute myocardial infarction patients[J].Eur Heart J,2006,27(7):779-788.
  • 7Keeley EC,Boura JA,Grines CL.Primary angioplasty versus intravenous thrombolysis therapy for acute myocardial infarction:a quantitative review of 23 randomised trials[J].Lancet,2003,361(9351):13-20.
  • 8Previtali M.Myocardial viability in ischemic heart disease:new directions and perspectives[J].Ital Heart J,2001,2(2):93-99.
  • 9Claridge MW,Hobbs SD,Quick CR,et al.ACE inhibitors increase type III collagen synthesis:a potential explanation for reduction in acute vascular events by ACE inhibitors[J].Eur J Vasc Endovasc Surg,2004,28(1):67-70.
  • 10Mccullough PA.Clinical applications of B-type natriuretic peptide levels in the care of cardiovascular patients.Minerva Cardioangiol,2004,52:479-489.

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