文拉法辛在广泛性焦虑患者中的应用效果研究

Study on application effect of venlafaxine treament on patients with generalized anxiety disorder

目的:分析文拉法辛治疗广泛性焦虑症患者的临床效果.方法:将福建省漳州市福康医院收治的102例广泛性焦虑患者随机分为治疗组(n=51)和对照组(n=51),其中对照组患者给予阿普唑仑治疗,治疗组患者口服文拉法辛治疗,4周为一个疗程,疗程结束后,比较两者患者的汉密尔顿焦虑量表评分、临床总有效率以及不良反应情况.结果:治疗4周后,治疗组患者的HAMA评分为(3.6±1.9)分,显著低于对照组的(6.4±2.4)分,差异有统计学意义(P<0.05);治疗组患者的显效率、有效率和总有效率分别为49.0%、41.2%、90.2%,对照组患者的显效率、有效率和总有效率分别为39.2%、25.3%、74.5%,两组比较,差异有统计学意义(P<0.05);治疗组不良反应发生率为11.7%,对照组不良反应发生率为13.6%,两组比较,差异无统计学意义(P>0.05).结论:文拉法辛治疗广泛性焦虑症效果显著,安全性高,值得临床推广.

AIM： To analyze the clinical effect of venlafaxine treament on patients with generalized anxiety disorder. METHODS：A total of 102 cases of generalized anxiety disorder admitted into Fukang Hospital of Zhangzhou in Fujian were selected and randomly divided into control group and treatment group, with 51 cases in each group. Patients in the control group were treated by alprazolam, while patients in the treatment group were treated by venlafaxine, with a course of treatment of four weeks. After the end of treatment, the Hamilton anxiety scale score, total efficiency and adverse reactions were compared. RESULTS： After 4 weeks of treatment, HAMA score of the treatment group was （3.6 ± 1.9） which was lower than （6.4 ± 2.4） of the control group, with statistically significant difference （ P〈0. 05）; Marked efficiency, efficiency and total efficiency of the treatment group were 49. 0%, 41. 2% and 90. 2% respectively, and those of the control group were 39.2%, 25.3%, 74.5%, with statistically significant difference between the two groups（ P〈0.05）;The adverse reactions was 11.7% in the treatment group, and that of the control group was 13. 6%, without statistically significant difference （ P〉0.05） . CONCLUSION：The clinical effect of Venlafaxine in the treatment of generalized anxiety disorder is significant and safe, and worthy of promotion.