甲氨喋呤与米非司酮联合治疗异位妊娠的临床效果分析

Clinical effect analysis of methotrexate combined with mifepristone in the treatment of ectopic pregnancy

目的:探讨甲氨喋呤与米非司酮联合治疗异位妊娠的临床效果.方法:选取四川省富顺县人民医院2013-04/2015-04收治的异位妊娠患者122例作为研究对象,将所选患者按入院单双号分为对照组(n=61)和研究组(n=61),对照组进行甲氨喋呤治疗,研究组进行甲氨喋呤联合米非司酮治疗,比较两组临床治疗效果.结果:比较两组患者治疗总疗效,研究组(95.08%)高于对照组(80.33%),差异有统计学意义(P<0.05).比较两组β-HCG指数恢复时间,研究组少于对照组,差异有统计学意义(P<0.05).比较两组患者并发症总发生率,研究组(3.28%)低于对照组(9.84%),差异有统计学意义(P<0.05).结论:临床治疗异位妊娠疾病可考虑将甲氨喋呤联合米非司酮方案作为首选,该方案疗效明显,且安全可靠,临床应用价值较高.

AIM：To investigate the clinical effect of methotrexate combined with mifepristone in the treatment of ectopic pregnancy. METHODS：A total of 122 patients with ectopic pregnancy admitted into Fushun People＇s Hospital of Sichuan Province from April 2013 to April 2015 were selected as the study objects, and randomly divided into control group and study group, with 61 cases in each group. The control group was treated by methotrexate, while study group was treated by mifepristone combined with methotrexate. The total effective rate of the two groups was compared. RESULTS：The total effective rate of the study group was 95.08% which was higher than 80.33% of the control group, with statistically significant difference between the two groups （ P〈0.05） . Recovery time of β-HCG of the study group was less than that of the control group with statistically significant difference （ P〈0.05）. Complication rate of the study group was 3.28% which was lower than 9.84% of the control group, with statistically significant difference （P〈0.05）. CONCLUSION： Clinical treatment of ectopic pregnancy disease can be considered as the first choice of methotrexate combined with mifepristone program, the curative effect of this method is obvious, safe and reliable, and the clinical value is high.