老年难治性心力衰竭患者BNP、hs-CRP水平与心功能的相关性及其临床意义

Clinical Significance and Correlation Refractory Heart Failure in Elderly Patients with BNP,hs-CRP Levels and Heart Function

目的:探究老年难治性心力衰竭(心衰)患者BNP、hs-CRP水平与心功能的相关性及其临床意义。方法:以我院心内科近两年收治的61例老年难治性心衰患者为临床研究对象,作为心衰组,另选20例健康志愿者作为对照组。心衰组患者按照NYHA分级的不同,从低到高分成A、B、C三组。对患者进行BNP与hs-CRP测定,并测定患者的心功能LVDD和LVEF。跟踪记录患者的心血管事件发生情况,比较患者BNP、hs-CRP、LVEF、LVDD水平的差异。结果:与对照组相比,心衰组患者的LVDD、BNP与hs-CRP指标显著较高而LVEF指标显著较低;A、B、C三组患者的LVDD、BNP与hs-CRP指标逐渐升高、LVEF水平逐渐下降;与无心血管事件患者相比,出现心血管事件患者的BNP、hs-CRP、LVDD水平显著较高,LVEF指标则显著低。差异均具有统计学意义(P<0.05)。结论:BNP与hs-CRP指标与老年难治性患者的心功能具有密切的关系,BNP、hs-CRP以及患者的LVEF、LVDD水平是临床诊断老年难治性心衰的重要标志物,具有重要的临床诊断价值。

Objective： To explore the elderly patients with refractory heart failure BNP,hs-CRP levels and cardiac functionand its clinical significance.Methods：61 cases of elderly patients with refractory heart failure Cardiology Hospital admitted nearlytwo years for the clinical study,as the CHF group,20 healthy volunteers alternative as a control group.According to differentgroups of patients with heart failure NYHA class,from low to high is divided into A,B,C three groups.Patients were BNP and hs-CRP measurement,and measurement of cardiac function in patients with LVDD and LVEF.Track record compared to the situationin patients with BNP hs-CRP,LVEF difference,LVDD levels in patients with cardiovascular events.Results：Compared withthe control group,LVDD,BNP and hs-CRP indicators of heart failure patients was significantly higher and significantly lowerLVEF indicators;A,B,C three groups of patients with LVDD,BNP and hs-CRP index gradually rise high,LVEF levels graduallydecreased;compared with patients without cardiovascular events,cardiovascular events in patients with BNP,hs-CRP,significantlyhigher LVDD level,LVEF indicators are significantly lower.The differences were statistically significant （P〈0.05）.Conclusion：BNP and hs-CRP index and cardiac function in elderly patients with refractory has a close relationship,BNP,hs-CRP and patientsLVEF,LVDD level of clinical diagnosis of refractory heart failure in the elderly an important marker has important clinicaldiagnostic value.