曲美他嗪联合血栓通对老年下肢动脉硬化闭塞症患者的疗效观察

Effects of Sibutramine Trimetazidine Combined with Xueshuantong Injection on Elderly Patients with Lower Extremity Arterial Occlusive Disease

目的:分析总结老年下肢动脉硬化闭塞症治疗中曲美他嗪联合血栓通的应用价值。方法:以80老年下肢动脉硬化闭塞症患者作为观察对象,并随机分为两组,对照组接受血栓通注射液治疗,观察组接受联合曲美他嗪及血栓通治疗,每组40例。对比两组治疗前后血清总胆红素(TB)及一氧化氮(NO)变化情况,并分析两组治疗总有效率及治疗不良反应发生率。结果:两组入组时TB及NO含量比较,差异未见统计学意义(P>0.05);而在接受治疗2周后,观察组TB及NO均高于对照组,差异存在统计学意义(P<0.05)。同时,观察组治疗总有效率明显高于对照组,差异存在统计学意义(P<0.05),而两组治疗不良反应发生率比较,差异未见统计学意义(P>0.05)。结论:曲美他嗪联合血栓通注射液可有效地提高老年下肢动脉硬化闭塞症的临床治疗效果。

Objective： To analyze and summarize the elderly patients with lower extremity arterial occlusive disease combinedwith trimetazidine trimetazidine and Xueshuantong application value.Methods：In 80 elderly patients with lower extremity arterialocclusion patients as the observation object,and were randomly assigned to two groups,the control group accepted Xueshuantonginjection in the treatment,the observation group received combined with trimetazidine trimetazidine and Xueshuantong treatment,40cases in each group.The changes of serum total bilirubin （TB） and nitric oxide （NO） were compared between the two groups beforeand after treatment,and the total effective rate and the incidence of adverse reaction in the two groups were analyzed.Results：Two groups in the TB and NO content comparison,the difference was not statistically significant （P〉0.05）;and after 2 weeks oftreatment,the observation group NO and TB were higher than the control group,the difference was statistically significant （P〈0.05）.At the same time,the total effective rate of the observation group was significantly higher than that in the control group,the differencewas statistically significant （P〈0.05）,and there was no significant difference in the incidence of adverse reactions between the twogroups （P〉0.05）.Conclusion：Trimetazidine combined with thrombus Tong injection is effective for the improvement of elderlypatients with lower extremity arteriosclerosis obliterans of clinical therapeutic effect.