增强T_1-FLAIR序列和磁化传递对比技术诊断脑微小转移瘤

Application value of contrast-enhanced T_1-FLAIR and MTC in the intracranial micrometastases

目的:对比分析增强T_1液体衰减反转恢复(T_1-FLAIR)序列和磁化传递对比(MTC)两种序列对脑内微小转移瘤的应用价值。方法:对60例患有脑转移瘤的病人行常规扫描后采用T_1-FLAIR和T_1WI+MTC序列增强扫描,分别统计增强后T_1-FLAIR和T_1WI+MTC序列显示转移瘤的数目、大小、位置等,并比较二者对微小转移瘤的显示能力及2种序列图像的病灶-背景的对比度/噪声(C/Ns)值。结果:60例脑转移瘤中,共计235个病灶,增强后MTC序列显示了231个病灶,显示率为98.3%,T_1-FLAIR序列显示了227个病灶,显示率为96.6%。T_1WI+MTC序列发现了T_1-FLAIR序列不能显示的4个病灶,而T_1-FLAIR序列证实了T_1WI+MTC序列误判的2个病灶。T_1WI+MTC图像病灶-背景的C/Ns值为29.85±6.43,T_1-FLAIR图像病灶-背景的C/Ns值为14.54±7.64,T_1WI+MTC序列的C/Ns值高于T_1-FLAIR序列的C/Ns值(t=7.05,P<0.05)。结论:增强T_1WI+MTC序列和增强T_1-FLAIR序列相互补充,二者结合能够最大程度满足微小转移瘤的显示和鉴别诊断的需要。

Objective：To analyze the application value of contrast - enhanced T1 fluid attenuated inversion recov-ery（T1 - FLAIR）and Magnetic transfer contrast（MTC）in the intracranial micrometastases. Methods：All 60 patients with intracranial metastases received MRI plain routine scans and contrast - enhanced T1 - FLAIR and T1 WI ＋ MTC scans. The numbers,size,and location of metastases were analyzed and the display abilities of two sequences for mi-crometastases and contrast - to - noise ratio（C/ Ns）of lesion - background on T1 - FLAIR and T1 WI ＋ MTC images were compared. Results：Total of 235 lesions were demonstrated in 60 patients with intracranial metastases. MTC ima-ges showed 231 lesions（98. 3% ）,while T1 - FLAIR showed 227 lesions（96. 6% ）. T1 WI ＋ MTC discovered 4 lesions which T1 - FLAIR cannot display. And T1 - FLAIR verified 2 lesions misjudged by MTC. C/ Ns of lesion - background on T1 WI ＋ MTC images（29. 85 ＆#177; 6. 43）is higher than C/ Ns on T1 - FLAIR images（14. 54 ＆#177; 7. 64）（t = 7. 05,P ﹤0. 05）. Conclusion：Contrast - enhanced T1 - FLAIR and T1 WI ＋ MTC become complementary,and the combination of two sequences can mostly satisfy the display of micrometastases and requirements of differential diagnosis.