Nme基因家族及其在口腔鳞癌中的研究进展

Research progress of Nme gene family and its application in oral squamous cell carcinoma

Nme（neoplasm metastasis）基因家族又曾被称为nm23（non-metastatic 23）基因家族,nm23基因是发现最早的肿瘤转移抑制基因。该基因家族成员的蛋白产物都具有二磷酸核苷激酶（nucleoside diphosphate kinase,NDPK）活性结构,目前发现有10个成员（Nme1~Nme10）。目前已知Nme基因家族编码的蛋白参与包括细胞生长、分化、代谢、信号转导等多个过程,在癌症的发生发展中扮演着重要的角色。目前研究最多的是Nme1和Nme2。研究发现肿瘤细胞分化和转移抑制功能与Nme1的关系最为密切。现就Nme（nm23）基因家族及其近年来在口腔鳞癌中的相关研究进展作一综述。

The Nme（neoplasm metastasis） gene family was previously known as the nm23（non-metastatic 23） gene family. The nm23 gene was the earliest tumor metastasis suppressor gene discovered by Steeg in 1988. All products of the 10 members（Nme1-Nme10） discovered so far of the gene family have a nucleoside diphosphate kinase（NDPK） active structure. Proteins encoded by the Nme gene family participate in processes including cellular differentiation, development, metabolism and signal transduction,and play an important role in the development of carcinoma. The Nme1 and Nme2 have been subjects of most relevant studies which show that the Nme1 isclosely associated with cellular differentiation and metastasis suppressor function in tumor. This paper provides an overview of studies in recent years on the Nme（nm23） gene family in oral squamous cell carcinomas.