137例甘露醇注射液不良反应分析

Analysis on 137 Cases of Adverse Drug Reactions of Mannitol Injection

目的：分析甘露醇注射液临床常见的不良反应特点和规律，提出有效预防措施以保证患者用药安全。方法对2015年7月1日~9月30日我市药品不良反应中心收集到的137例甘露醇注射液不良反应，按照人群性别与年龄、症状、累及系统-器官、发生时间、新的或严重的不良反应等方面进行分析。结果137例甘露醇注射液不良反应多数发生于46岁以上患者，男性比例与女性比例相当；多数为高剂量使用患者；累及系统-器官主要为泌尿系统损害、皮肤及其附件损害、神经系统损害、全身性损害；不良反应发生时间多为用药后30 min内。结论应进一步完善药品说明书中老年患者用法用量说明，关注特殊人群用药，规范临床用药并加强患者监护。

Objective To analyze the common characteristics and rules of adverse drug reactions （ADRs） induced by mannitol injection, propose effective preventive measures of ADRs, and ensure medication safety of patients.Methods 137 cases of ADRs induced by mannitol injection from our center from July 1st, 2015 to September 30th, 2015 were analyzed in terms of genders and ages, symptoms, system-organs, time of occurring, new or serious ADRs.Results Most ADRs induced by mannitol injection occurred in patients over 46 years old, which happened equally between the male and the female. ADRs often occurred in patients with high doses. The main clinical manifestations of ADRs induced by mannitol injection involved urinary system disorders, skin and appendages disorders, nervous system disorders, and general disorders. ADRs mostly occurred within 30 min.Conclusion The usage and dosage in drug instructions for middle-old aged patients should be further improved, the medication of special groups should be paid more attention, clinical medication should be standardized and monitoring should be strengthened.