热毒宁注射液对小儿轮状病毒性肠炎心肌酶谱的影响以及临床疗效研究

The effect of Reduning injection on myocardial enzyme in children with rotavirus enteritis and its clinical significance

[目的]观察热毒宁注射液治疗小儿轮状病毒性肠炎的临床疗效以及对小儿心肌酶谱的影响。[方法]选取2013年6月-2015年4月我院儿科治疗的轮状病毒肠炎患儿124例,使用数字法随机分为对照组和热毒宁注射液治疗观察组,每组62例。白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、乳酸脱氢酶（LDH）、肌酸激酶（CK）及肌酸激酶同功酶（CK-MB）使用酶联免疫吸附法（ELISA）测定,比较2组的临床疗效。[结果]观察组腹泻、退热和住院时间分别为（2.57±0.59）d、（2.05±0.36）d和（4.86±1.07）d,均显著低于对照组的（3.68±0.81）d、（2.74±0.61）d和（6.08±1.34）d（P〈0.05）。观察组临床治疗有效率为93.5%,显著高于对照组的80.6%（P〈0.05）。治疗前2组IL-6和TNF-α表达差异无统计学意义（P〉0.05）。治疗后2组IL-6和TNF-α表达均减低（P〈0.05和P〈0.01）,但治疗后观察组对IL-6和TNF-α表达的减低作用显著优于对照组（P〈0.05）。治疗前对照组和治疗组LDH、CK和CK-MB心肌酶谱指标表达差异无统计学意义（P〉0.05）,治疗后2组上述心肌酶谱指标均显著减低（P〈0.05和P〈0.01）,但观察组对上述心肌酶谱指标的改善作用显著优于对照组（P〈0.05）。[结论]热毒宁注射液治疗小儿轮状病毒肠炎可以抑制炎症反应,保护患儿心肌损伤,临床疗效显著,值得临床推广使用。

[Objective]To observe the effect of Reduning injection on myocardial enzyme in children with rotavirus enteritis and explore its clinical efficacy.[Methods]124cases of children with rotavirus enteritis were sellected in this study.Children were randomly divided into control group（n=62）and Reduning injection observation group（n=62）.IL-6,TNF-α,LDH,CK,and CK-MB were detected by ELISA analysis.The clinical effect was compared.[Results]The diarrhea time,abatement time of fever and hospitalization time was（2.57±0.59）d,（2.05±0.36）d,（4.86±1.07）d in observation group,which was lower than that of（3.68±0.81）d,（2.74±0.61）d,（6.08±1.34）d in control group（P〈0.05）.The rate of clinic effects was 93.5%in observation group,which was better than 80.6%in control group（P〈0.05）.After treatment,IL-6,TNF-α,LDH,CK,and CK-Mb were lower in treatment group than those in control group（P〈0.05）.[Conclusion]Reduning injection can inhibit inflammatory response and protect myocardial injury in the treatment of infantile rotavirus enteritis,with significantly clinical efficacy.And it is worthy of clinical application.