DCEP方案治疗复发或难治老年多发性骨髓瘤疗效观察

Observation of curative effect by DCEP regimen in the treatment of relapsed or refractory senile multiple myeloma

目的观察DCEP方案治疗复发或难治老年多发性骨髓瘤(MM)的临床效果及不良反应。方法 19例复发或难治的老年MM患者,均采用DCEP方案治疗,观察疗效,并按WHO不良反应分级标准判断不良反应。结果经治疗,11例患者部分缓解(PR),6例病情稳定(SD),2例病情进展(PD),总有效率为57.9%。不良反应主要为中性粒细胞减少,均可耐受。结论 DCEP方案作为挽救性治疗复发或难治骨髓瘤的方案之一,不良反应可耐受,可使复发或难治老年MM患者部分受益。

ObjectiveTo observe clinical effect and adverse reactions by DCEP regimen in the treatment of relapsed or refractory senile multiple myeloma （MM）.MethodsA total of 19 relapsed or refractory senile MM patients received DCEP regimen for treatment. Their curative effects were observed, and adverse reactions were evaluated by WHO grading standard.ResultsAfter treatment, there were 11 partial remission （PR） cases, 6 stable disease （SD） cases, and 2 progressive disease （PD） cases, with the total effective rate as 57.9%. Main adverse reactions included tolerant decreased neutrophil.ConclusionAs one of salvage treatments for relapsed or refractory senile MM, DCEP regimen provides tolerant adverse reactions, and it benefits patients with relapsed or refractory senile MM.