重组人脑利钠肽对急性心力衰竭患者血浆半乳糖凝集素-3、内皮素-1、胱抑素C水平及心功能的影响

Influence of rhBNP on plasma Gal-3,ET-1,CysC levels and cardiac function in patients with acute heart failure

目的:探讨重组人脑利钠肽(rhBNP)对急性心力衰竭患者血浆半乳糖凝集素-3(Gal-3)、内皮素-1(ET-1)和胱抑素C(CysC)及心功能的影响。方法:将126例急性心力衰竭患者随机分为rhBNP组和对照组,每组各63例。rhBNP组在传统抗心力衰竭治疗基础上应用冻干rhBNP治疗,对照组在传统抗心力衰竭治疗基础上应用多巴酚丁胺治疗。观察2组患者治疗前后血浆Gal-3、ET-1、CysC水平、心功能参数变化情况、临床疗效及药物不良反应情况。结果:治疗72h后,rhBNP组心功能改善的总有效率显著高于对照组(88.89%vs.68.25%,P<0.05);2组血浆Gal-3、ET-1、CysC水平均有下降,但rhBNP组较对照组下降更显著(P<0.05)。rhBNP组左室射血分数(LVEF)、左室舒张末内径(LVEDD)治疗后均较治疗前显著改善,且改善程度优于对照组(P<0.05)。结论:rhBNP治疗可有效降低急性心力衰竭患者血浆Gal-3、ET-1和CysC水平,明显改善心功能,具有重要的临床应用价值。

Objective：To explore the influence of rhBNP on plasma Gal-3,ET-1,CysC levels and cardiac function in patients with acute heart failure.Method：One hundred and twenty-six cases of patients with acute heart failure were randomly divided into rhBNP group and control group,and 63 cases in each group.The patients were treated with freeze-dried rhBNP in research group and dobutamine were transfused in control groupon the basis of conventional treatment.The levels of plasma Gal-3,ET-1and CysC,the changes of heart parameters,the clinical curative effects,the adverse drug reactions were observed in two groups.Result：After 72 htreatment,the total effective rate of cardiac function improvement was 88.89%in rhBNP group,significantly higher than that（68.25%）in control group（P〈0.05）.The levels of plasma Gal-3,ET-1and CysC were significantly decreased in two groups（P〈0.05）,and the falling extents in rhBNP group were greater than that in control group（P〈0.05）.Compared with pre-treatment,LVEF and LVEDD were significantly improved after treatment in rhBNP group（P〈0.05）,and the degrees of improvement were higher than those in control group（P〈0.05）.Conclusion：RhBNP can effectively reduce the levels of plasma Gal-3,ET-1 and CysC and improve their heart functions in patients with acute heart failure,RhBNP has the important clinical application value.