高重力下成骨细胞的力学生物学响应

The mechanobiology responses of osteoblasts under hypergravity

骨适应性力学环境中,成骨细胞作为骨形成的主要功能细胞,也是感应力学载荷的主要细胞之一。目前随着科技的发展,越来越多的航天员、飞行员等暴露于高重力环境中。为了更好了解和认识高重力下成骨细胞的力学生物学响应,综述高重力下成骨细胞形态及增殖、基因表达、细胞因子分泌以及信号转导通道等力学生物学方面的研究进展,为高重力环境下骨组织的力学生物学研究提供思路和准备。

In the environment of adaptive mechanics,osteoblasts,which are the main functional cells of bone formation,are one of the main cells in response to the mechanical loading. With the development of technology,more and more astronauts,pilots and other are exposed to the hypergravity environment. In order to better understand the mechanobiology response of osteoblasts under hypergravity,this paper reviews the mechanobiological research progress in morphology,gene expression,cytokine secretion and signal transduction pathways of ostoblasts,so as to thoughts and preparations for mechanobiology research of bone tissues in hypergravity environment.