乙型肝炎病毒感染者体外受精助孕后子代垂直传播风险

Vertical transmission risk of hepatitis B virus infection in children born to hepatitis B virns-infected parent（s） after in vitro fertilization

目的：调查体外受精（IVF）助孕出生的 HBV感染者子代垂直感染风险。方法收集2008年1月至2013年12月在郑州大学第三附属医院生殖医学中心IV F助孕成功并顺利出生的221例产妇，纳入标准为夫妇一方或双方HBsAg阳性，且HBV DNA＜1×104拷贝／mL。通过电话方式随访子代接种乙型肝炎疫苗免疫及 HBV感染情况。结果172例产妇成功随访，49例产妇失访。224名出生子代HBsAg均为阴性，其中1名婴儿抗‐HBe和抗‐HBc阳性。结论 HBV感染者通过IVF助孕，不会增加出生子代病毒垂直传播风险。

Objective To investigate the risk of hepatitis B virus （HBV） infection in the children born to HBV‐infected parent （s） after in vitro fertilization （IVF） .Methods From January 2008 to December 2013 , in the reproductive medicine center of the Third Affiliated Hospital of Zhengzhou University ,the medical history of 221 mothers by IVF were collected .Inclusion criteria were at least one of the parents was positive for hepatitis B surface antigen （HBsAg） ,and HBV DNA〈1 ＆#215; 104copies/mL . Hepatitis B vaccination status and HBV infection status of children were followed by telephone .Results One hundred and seventy‐two cases were followed up successfully ,and 49cases were lost .Two hundred and twenty‐four cases of children were HBsAg negative ,but one of them showed hepatitis B virus e antibody and hepatitis B virus core antibody positive .Conclusions The vertical transmission risk of HBV infection of children born to HBV‐positive patent（s） by IVF did not increase .