血清基质金属蛋白酶及胰岛素样生长因子相关指标与脑梗死合并肺部感染的关系分析

Relationship between serum matrix metalloproteinase,insulin-like growth factor related indexes and cerebral infarction complicated with pulmonary infection

目的分析及研究血清基质金属蛋白酶(MMP)及胰岛素样生长因子(IGF)相关指标与脑梗死合并肺部感染的关系,为脑梗死合并肺部感染的诊断提供依据。方法选取2014年1月-2015年8月于医院进行诊治的52例脑梗死合并肺部感染患者为A组,同时期52例脑梗死患者为B组,52名体检健康者为C组,比较A组、B组及C组的血清MMP及IGF相关指标,并比较A组中轻度、中度及重度肺部感染患者的血清检测结果,并以logistic分析血清MMP及IGF相关指标与脑梗死合并肺部感染的关系。结果 A组血清MMP-1、MMP-2、MMP-3及MMP-9水平分别为(6.18±0.56)ng/ml、(18.59±1.76)ng/ml、(25.35±2.72)ng/ml及(168.82±12.39)ng/ml,其均高于B组及C组,B组的水平则高于C组,同时A组TIMP相关指标均高于B组及C组,B组则高于C组,IGF相关指标则低于B组及C组,B组则低于C组,A组中不同程度肺部感染者也存在明显差异,且经Logistic分析显示,血清MMP及IGF相关指标均与脑梗死合并肺部感染有密切的关系差异有统计学意义(P<0.05)。结论脑梗死合并肺部感染患者血清MMP及IGF相关指标呈现异常的表达状态,且上述血清指标均与本病有密切的关系。

OBJECTIVE To analyze and study the relationship between serum matrix metalloproteinase（MMP）,insulin-like growth factor（IGF）related indexes and cerebral infarction complicated with pulmonary infection,in order to provide evidence for the diagnosis of cerebral infarction complicated with pulmonary infection.METHODS A total of 52 patients with cerebral infarction complicated with pulmonary infection in hospital from Jan.2014 to Aug.2015 were selected as group A,52 patients with cerebral infarction were selected as group B,and 52 healthy persons with health examination were selected as group C.The serum MMP and IGF related indexes of group A,group B and group C were compared,then the serum detection results of group A with mild,moderate and severe pulmonary infection were compared too,and the relationship between serum MMP,IGF related indexes and cerebral infarction complicated with pulmonary infection were analyzed by logistic analysis.RESULTS The serum MMP-1,MMP-2,MMP-3and MMP-9levels of group A were respectively（6.18±0.56）ng/ml,（18.59±1.76）ng/ml,（25.35±2.72）ng/ml and（168.82±12.39）ng/ml,and they were all higher than those of group B and group C,and the levels of group B were all higher than those of group C.The TIMP related indexes of group A were all higher than those of group B and group C too,and the levels of group B were all higher than those of group C.The IGF related indexes of group A were all lower than those of group B and group C,and the levels of group B were all lower than those of group C.The detection levels of group A with different infection degrees of pulmonary infection all had obvious differences too,and the serum MMP and IGF related indexes all had close relationship to cerebral infarction complicated with pulmonary infection by logistic analysis（P〈0.05）.CONCLUSION The serum MMP and IGF related indexes and cerebral infarction complicated with pulmonary infection all show abnormal expression state,so those serum indexes all have close relationship to the disease.