幽门螺杆菌感染对冠心病患者相关指标及颈动脉硬化的影响

Effect of Hp infection on coronary heart disease related indicators and carotid atherosclerosis of patients

目的探讨幽门螺杆菌(Hp)感染对冠心病患者各项指标和血脂水平变化及颈动脉硬化的影响,分析Hp感染对冠心病颈动脉硬化影响的可能机制。方法选取2014年8月-2015年8月于医院诊治的冠心病患者200例,分为Hp感染组与非Hp感染组,各100例,检测患者血清高敏C-反应蛋白(hs-CRP)、尿酸(UA)、纤维蛋白原(FIB)、氧化低密度脂蛋白(oxLDL)和血脂水平变化,超声检查是否存在颈动脉硬化,采用SPSS19.0软件进行统计分析。结果 Hp感染组患者hs-CRP、UA、FIB、oxLDL和总胆固醇(TC)、三酰甘油(TG)、低浓度脂蛋白(LDL-C)高于非Hp感染组(P<0.05),Hp感染组颈动脉硬化发生率为68.00%,高于非Hp感染组的53.00%,Hp感染组不稳定斑块检出率23.00%,高于非Hp感染组7.00%,内中膜增厚检出率为11.00%,低于非Hp感染组22.00%,比较差异有统计学意义(P<0.05)。结论冠心病患者存在Hp感染时hs-CRP、UA、FIB、oxLDL和血脂水平及颈动脉硬化发生率明显升高,重度感染者表现更为明显,可能是Hp感染后通过影响机体炎症反应及脂质代谢等促进了颈动脉硬化的发生及发展。

OBJECTIVE To investigate the effect of Helicobacter pylori（Hp）infection in patients with coronary heart disease related indicators,blood lipid and carotid atherosclerosis,and to analyze the possible mechanism of the impact of Hp infection on carotid atherosclerotic coronary heart disease.METHODSA total of 200 cases of patients with coronary heart disease were selected from Aug.2014 to Aug.2015 in our hospital,and they were divided into Hp infection group and non-Hp infection group with 100 patients in each group.The changes of serum hs-CRP,UA,FIB,oxLDL,blood lipid and the ultrasound presence of carotid atherosclerosis were detected.RESULTSHsCRP,UA,FIB,oxLDL,TC,TG and LDL-C of Hp infection group were higher than that of the non-Hp infection group（P〈0.05）;Prevalence of carotid atherosclerosis of the Hp infection group was 68.00% which was higher than 53.00% of the non-Hp infection group.Unstable plaque detection rate of the Hp infection group wes 23.00% which was higher than 7.00% of the non-Hp infection group.Intima-media thickness detection rate of the Hp infection group was 11.00% which was lower than 22.00% of the non-Hp infection group.The differences were significant（P〈0.05）.CONCLUSION The prevalence rates of hs-CRP,UA,FIB,oxLDL,blood lipid levels and carotid arteriosclerosis in Hp infection for patients with coronary heart disease increase significantly,and the conditions for severe infection performance are more apparent.It probably promotes the development and occurrence of carotid sclerosis by influencing the body＇s inflammatory response and lipid metabolism after Hp infection.