系统性红斑狼疮活动期患者采用黄芩漱口液预防口腔真菌感染的临床疗效观察

Clinical observation of effects of huangqin mouthwashes on prevention of oral fungal infection in patients with systemic lupus erythematosus

目的探讨黄芩漱口液对系统性红斑狼疮活动期患者预防口腔真菌的作用,为系统性红斑狼疮活动期患者寻找更有效的预防口腔真菌感染的方法和临床应用提供基础性依据。方法 2011年1月-2014年1月医院收治系统性红斑狼疮活动期患者102例随机分为3个组,分别为黄芩漱口液组、碳酸氢钠组以及空白对照组,每组患者34例,且各组别的患者使用相应漱口液的含漱时间一致,并记录患者发生口腔真菌感染的概率,以及感染和治愈的时间。结果系统性红斑狼疮活动期患者口腔真菌感染发生的频率:黄芩漱口液组为8.82%,碳酸氢钠组为14.70%,空白对照组为47.06%,3组间差异有统计学意义(P<0.05),且黄芩漱口液组与碳酸氢钠组发生感染的概率均明显低于空白对照组(P<0.05);3组患者口腔感染真菌发生的天数以及治愈时间比较,其差异具有统计学意义(P<0.05),且黄芩漱口液组、碳酸氢钠组的患者出现口腔真菌感染的时间均比空白对照组较晚(P<0.05),治愈时间也比空白对照组短(P<0.05),而黄芩漱口液组的患者发生口腔真菌感染的时间比碳酸氢钠组较晚(P<0.05),治愈时间也比碳酸氢钠组较短(P<0.05)。结论系统性红斑狼疮活动期患者使用黄芩漱口液可以有效的降低其自身应用糖皮质激素期间所发生的口腔真菌感染率。

OBJECTIVE To investigate the effects of huangqin mouthwashes solutions on prevention of oral fungal infection in patients with active systemic lupus erythematosus（SLE）,and to explore the potent methods to prevent oral infections,so as to provide basic evidence for clinical application in the future.METHODS A total of 102 patients with active systemic lupus erythematosus in our hospital from Jan.2011 to Jan.2014 were randomly divided into the huangqin mouthwashes group,soda water group and control group,with 34 cases in each group.The rinse time was the same for each group.The incidence of oral fungal infections,the infection days and its cure time were recorded.RESULTS The incidence of oral fungal infection was 8.82%,14.70% and 47.06% in huangqin mouthwashes group,soda group and control group,respectively.The rates of oral fungal infections among the three groups had significant differences（P〈0.05）.Comparing with control group,the incidence of oral fungal infection in huangqin mouthwashes group and soda group was significantly decreased（P〈0.05）.The infection days of oral fungal infection and cure time among the three groups had significant differences（P〈0.05）.Comparing with control group,the occurrence of oral fungal infection was later and the cure time was shorter in huangqin mouthwashes group and soda water group（P〈0.05）,especially in the huangqin mouthwashes group（P〈0.05）.CONCLUSION The huangqin mouthwashes can significantly reduce the incidence of oral fungal infections in the patients with active systemic lupus erythematosus who received glucocorticoid therapy.