手术切口感染患者血清及创口分泌物炎症介质的变化研究

Change of serum and wound secretion inflammation mediators of patients with surgical incision infections

目的研究手术切口感染患者血清及创口分泌物炎症介质的变化,为临床用药提供参考依据。方法选取2014年1月-2015年9月医院收治46例手术切口感染患者为观察组,同时期的46例手术切口未发生感染者为对照组,然后将观察组血清及创口分泌物、观察组的血清炎症介质水平进行比较,并比较观察组中轻度、中度及重度感染患者的血清及创口分泌物炎症介质水平。结果观察组患者血清炎症介质中白细胞介素(IL-1β)为(2.89±0.35)pg/ml、IL-6(8.95±1.23)pg/ml、肿瘤坏死因子α(TNF-α)为(1.84±0.2)ng/ml及前列腺素E2(PGE2)为(184.64±20.59)pg/ml、P物质(SP)为(7.20±0.68)μg/ml、缓激肽(BK)为(7.87±1.24)μg/l,均高于对照组的血清表达水平,观察组轻度、中度及重度感染患者的血清及创口分泌物炎症介质均存在明显差异,以上差异均有统计学意义(P<0.05)。结论手术切口感染患者血清及创口分泌物炎症介质的变化较大,感染严重程度对其表达影响较大,对于抗感染治疗措施的制定有积极的临床指导意义。

OBJECTIVE To study the change situation of serum and wound secretion inflammation mediators of patients with surgical incision infections,so as to provide reference frame for the clinical medication.METHODS Totally 46 patients with surgical incision infections in hospital from Jan.2014 to Sep.2015 were selected as the observation group,another 46 patients without surgical incision infections at the same time were selected as the control group.Then the serum and wound secretion inflammation mediators of observation group and control group were compared,and the serum and wound secretion inflammation mediators of observation group with mild,moderate and severe infection were compared too.RESULTS The serum inflammation mediators including interleukin-1β（IL-1β）,interleukin-6（IL-6）,tumor necrosis factor-α（TNF-α）and prostaglandin E2（PGE2）,substance P（SP）,bradykinin（BK）of observation group were respectively（2.89±0.35）pg/ml,（8.95±1.23）pg/ml,（1.84±0.2）ng/ml and（184.64±20.59）pg/ml,（7.20±0.68）μg/ml,（7.87±1.24）μg/L,and they were all higher than those of control group,and the serum and wound secretion inflammation mediators of observation groups with mild,moderate and severe infection had significant differences too（P〈0.05）.CONCLUSION The level of serum and wound secretion inflammation mediators of patients with surgical incision infections changed significantly and the severity of inflammation had great influence on the expression of those mediators.These indicators have clinical significance when guiding the anti-infection measures.