急性呼吸道感染患儿红细胞免疫与黏膜纤毛结构的变化研究

Changes of erythrocyte immune and mucosal cilia structure of children with acute respiratory infection

目的研究及观察急性呼吸道感染患儿红细胞免疫与黏膜纤毛结构的变化情况,为疾病的诊断与治疗提供依据。方法选取2014年2月-2015年6月于医院诊治75例急性呼吸道感染患儿为观察组,选取同时期75名健康同龄儿童为对照组,将两组儿童的红细胞免疫与黏膜纤毛结构指标进行检测与比较,并比较观察组患儿呼吸道感染不同严重程度与感染部位检测结果,数据采用SAS5.0软件进行统计分析。结果观察组患儿红细胞免疫黏附促进因子(FEER)为(60.25±3.98)%、协同肿瘤红细胞花环率(ATER)为(55.34±4.70)%、直向肿瘤红细胞花环(DTER)(29.62±2.88)%及红细胞C3b受体花环(RBC-C3bR)为(15.65±1.74)%,均低于对照组,黏膜纤毛结构指标异常率观察组高于对照组,差异均有统计学意义(P<0.05);呼吸道感染不同严重程度与感染部位者的检测结果也存在明显差异,差异有统计学意义(P<0.05)。结论急性呼吸道感染患儿红细胞免疫处于较差的状态,而黏膜纤毛结构异常情况也较明显,应给予充分重视。

OBJECTIVE To study and observe the changes of erythrocyte immune and mucosal cilia structure of children with acute respiratory infection,in order to provide evidence for the diagnosis and treatment.METHODSA total of 75 children with acute respiratory infection in our hospital from Feb.2014 to Jun.2015 were selected as observation group,and another 75 healthy children with same age at the same time were selected as control group.The erythrocyte immune and mucosal cilia structure of the children in the two groups were detected and compared,then the detection results of the observation group with different severity of infection and infection sites were compared.The results were statistically analyzed by software SPSS5.0.RESULTSThe erythrocyte immune indexes including regulator factor enhance rate（FEER）,associated tumor erythrocyte rosette（ATER）,direct tumor erythrocyte rosette（DTER）and red blood cell C3breceptor（RBC-C3bR）of the observation group were respectively（60.25±3.98）%,（55.34±4.70）%,（29.62±2.88）% and（15.65±1.74）%,which were all lower than those of the control group,and the abnormal rate of mucosal cilia structure were higher than that of the control group.The differences were all significant（P〈0.05）.The detection results of children with different severity of infection and infection sites also had significant differences（P〈0.05）.CONCLUSION The erythrocyte immune of children with acute respiratory infection shows worse state,and the abnormal situation of mucosal cilia structure are obvious,so enough attention should be paid to them.