百草枯中毒致肺损伤与免疫细胞功能紊乱关系的研究进展

Progress on the relationship between lung injury and immunocyte dysfunction induced by paraquat poisoning

百草枯（PQ）是一种广泛应用的除草剂，毒性强、中毒致死率高，急性肺损伤（ALI）是其主要致死原因。免疫细胞作为机体对外防御及调节体内稳态的基础，PQ中毒可诱导其功能紊乱，表现为巨噬细胞功能异常、中性粒细胞异常活化、Thl7细胞诱导激活及促炎因子释放、早期B细胞激活及后期功能抑制、NK细胞功能抑制，以上环节均可能是PQ中毒肺损伤的重要机制。因此，免疫细胞功能紊乱可能是PQ致肺损伤的重要原因。

Paraquat is a widely used herbicide, which is high toxic and lethal. Acute lung injury （ALI） is the main cause of death. As the basis of defense and homeostasis regulation in human body, the dysfunction of immunocyte could be induced by paraquat poisoning, for instance, macrophage dysfunction, abnormal activation of nentrophils, activation of Th17 cells and release of prointlammatory cytokines, activation of B ceils in early stage and inhibition in later stage, and inhibition of NK cells. More importantly, immunocyte dysfunctionabove is likely to be the critical mechanism of ALI. Therefore, immunocyte dysfunction could be the key etiological factor of paraquat - induced ALI.