摘要
为提高单宁酸的脂溶性和生物利用度,制备了单宁酸缓释微胶囊。对该微胶囊进行了扫描电子显微镜测试,考察了单宁酸缓释微胶囊在不同极性溶剂、释放介质、释放环境温度下的释放特性,并研究了其在猪油基质中的抗氧化活性。结果表明,该产品具有较好的包封效果,单宁酸微胶囊的缓释能力为非极性溶剂>极性溶剂、模拟胃液>模拟肠液,30℃下缓释效果最佳。通过控制释放,单宁酸缓释微胶囊的抗氧化能力更持久,添加0.06%的单宁酸缓释微胶囊,其抗氧化作用略强于0.02%抗氧化剂264(BHT)。
Controlled releasing microcapsules containing their lipid solubility and bioavailability. The excellent tannic acid were prepared in order to improve sealing property of the microcapsules was observed with SEM. The stable temperature of the microcapsules was observed to be 92.6 ℃ with DSC. The relea- sing property of microcapsules was investigated in different polar solvents, release media and ambient temperatures. The results showed that the sustained releasing ability of microcapsules containing tannic acid followed the orders: non-polar solvent 〉 polar solvent, simulated gastric fluid 〉 simulated intesti- nal fluid. The temperature had a negligible effect on the sustained-release rate in the low temperature range. The anti-oxidative capacity of microcapsules was more durable by controlling the release rate in the lard. The antioxidant activity of microcapsules containing 0.06% tannic acid was slightly stronger than that containing 0.02% antioxidant 264 (BHT).
出处
《黑龙江大学自然科学学报》
CAS
北大核心
2016年第3期381-385,共5页
Journal of Natural Science of Heilongjiang University
基金
黑龙江省自然科学基金资助项目(B201001)
哈尔滨商业大学研究生创新科研项目(YJSCX2014-330HSD)
关键词
单宁酸
缓释微胶囊
释放性能
tannic acid
sustained release microcapsules
releasing property