透皮促渗中药挥发油的化学成分与中药药性关联性研究

Association between chemical composition of essential oil with penetration enhancement effect and drug properties of traditional Chinese medicine

前期研究发现中药挥发油的透皮促渗效果与来源中药的药性存在关联性。化学成分是中药药性的物质基础,该文进一步考察了透皮促渗中药挥发油的化学成分与中药药性之间的关联性。采用水蒸气蒸馏法制备中药挥发油,测定了其相对密度和折光率等理化参数,采用GC-MS分析了20种中药挥发油的组成成分,将其按照骨架特征和官能团的不同分成12种类别,然后通过逐步Logistic回归分析,研究药性与成分类别之间的规律。结果表明,五味、四气以及归经均与挥发油中不同类别的成分存在关联性(P<0.05),来源中药药性与挥发油的成分类别存在明显的相关性和规律性。

The results of previous studies showed potential correlations between the penetration enhancement effect of essential oils and the drug properties of traditional Chinese medicine based on the data mining method. As chemical composition is the material basis of drug properties of traditional Chinese medicine,this article further analyzed the correlation between the chemical composition of essential oils and the drug properties. Firstly,essential oils were extracted by steam distillation,and then physicochemical parameters of essential oils,such as relative density and refractive index,were measured. The chemical components of 20 essential oils were analyzed by GC-MS,and divided into 12 categories according to skeleton features and functional groups. Finally,Logistic regression analysis was applied to reveal the correlations. The results proved that five flavors,four tastes and channel tropisms showed the correlation with chemical composition of essential oils（ P〈0. 05）. In conclusion,there were obvious correlations and regularity between the drug properties of traditional Chinese medicine and the chemical composition of essential oils.