摘要
药物转运体在体内药物的吸收(absorption)、分布(distribution)、代谢(metabolism)及排泄(excretion)的过程(ADME)中发挥着关键的作用。转运体在各组织器官的不同分布以及其基因多态性,导致某些药物的吸收、分布、代谢和排泄过程产生明显的个体差异。随着药物基因组学的快速发展,关于转运体基因多态性的研究报道越来越多。本文对近年来人体主要药物转运体基因多态性在药动学和药效学中的影响研究进行综述。
Drug transporters play a key role in absorption,distribution,metabolism and excretion process（ADME process）of drugs.Different distribution of transporters in tissues and organs as well as its genetic polymorphisms can result in individual differences of absorption,distribution,metabolism and excretion of drugs significantly.With rapid development of pharmacogenomics,researches of transporters＇ genetic polymorphisms have been more and more reported.In this paper,we will summarize influences of transporters＇ genetic polymorphisms on pharmacokinetics and pharmacodynamics in recent few years.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2016年第13期1144-1148,1150,共6页
Chinese Journal of Hospital Pharmacy
关键词
转运体
基因多态性
药动学
transporters
genetic polymorphisms
pharmacokinetics
