无机纳米材料及作为药物载体的抗氧化作用研究进展

Progress of Antioxidant Effects of Inorganic Nanomaterials and Their Use as Nanocarriers for Drug Delivery

机体氧化应激响应是导致许多慢性疾病发生的原因,其主要的治疗方式是采用抗氧化药物治疗。本文综述了无机纳米材料的分类及其在递送抗氧化药物方面的应用,并介绍了无机纳米载体本身的抗氧化作用机制。无机纳米载体在实现靶向给药、缓释给药、提高难溶性药物溶解度与稳定性方面表现出良好的应用前景,有利于提高抗氧化药物的疗效。

Oxidative stress response of the body is a source of many chronic diseases. Taking antioxidants is the currently main methods for treatment of the oxidative stress-related diseases. The classification of various inorganic nanomaterials and their applications to delivery of antioxidants are reviewed in this paper. Antioxidant mechanism of the inorganic nanomaterial itself is also introduced. Inorganic nanocarriers show good prospects in delivery of poorly soluble antioxidants because of the abilities of targeting delivery, sustained-release delivery and improvements of solubility and stability, which are useful to improve the efficacy of antioxidant drugs.