慢性HBV感染者HBeAg与ALT、AST检测结果分析

Analysis on the test results of HBeAg,ALT and AST in the population with chronic hepatitis B infection

目的探讨慢性乙肝病毒（hepatitis Bvirus，HBV）感染者HBeAg阳性率和丙氨酸氨基转移酶（ALT）、天门冬氨酸氨基转移酶（AST）水平。方法对居民健康体检发现的HBsAg阳性者用酶联免疫吸附法（ELISA）检测乙肝病毒血清标志物（HBV-M），用试剂盒（速率法）检测丙氨酸氨基转移酶（ALT）、天门冬氨酸氨基转移酶（AST）。结果共检测HBsAg阳性者3721例，其中男性2008例，女性1713例，平均（44．03±8．54）岁。HBeAg阳性605例，阳性率为16．26％，其中男性和女性阳性率分别为18．13％，14．07％，男女差异有统计学意义（P〈0．01）。HBeAg阳性组的ALT、AST平均值均〉HBeAg阴性组（P〈0．01）。HBeAg阳性组ALT、AST2〉80u／L的异常率均高于阴性组，差异有统计学意义（P〈0．01）。男性ALT、AST平均值和异常率（〉40u／L）均大于女性，差异有统计学意义（P〈0．01）。感染者ALT／AST为1．07，其中，HBeAg阳性与阴性组分别为1．28、1．04；10-40岁年龄组均〉1，〈10岁组和50岁以上年龄组均〈1。结论慢性HBV感染者以HBeAg阴性为主，HBeAg阳性率存在性别差异，HBeAg阳性者和大年龄的感染者肝功能损害更明显。

Objective To explore the HBeAg prevalence rate and the level of ALT and AST in the population with chronic hepatitis B infection. Methods BV-M was detected by ELISA assay while ALT and AST were tested in the popula tion with HBsAg positive. Results A total of 3 721 persons with HBsAg positive were investigated,2 008 males and 1 713 females,the average age was 44.03±8.54. 605 cases were HBeAg positive,with the prevalence rate at 16.26%o There was significant difference between the prevalence rate in males and females, 18.13% and 14.07% respectively（ P 〈 0.01）The average value of both ALT and AST among HBeAg-positive persons was higher than that among negative persons（ P 〈0.01）. The average value and the abnormal rate （〉40 u/L）of ALT and AST were higher in males than in that females（ P 〈0.01）. The value of ALT/AST was 1.07 in infected population,while 1.28 in HBeAg positive group and 1.04 in negative group,〉1 in the age group 10-40 and 〈1 in the age groups under 10 and over 50. Conclusion Most infected persons with HBV are HBeAg negative. The prevalence rates of HBeAg are different between males and females. The threat of liver dysfunction is more evidently in persons with HBeAg-positive and elder infected persons.