生熟五味子在补益方中补肾作用比较

Comparison of tonifying kidney effect between raw and processed Schisandra chinensis in tonic prescriptions

目的比较五子衍宗丸、六味丸中分别用生熟五味子对肾阳虚、肾阴虚小鼠作用的差异,从复方层面上为五味子"生熟异用"的临床应用提供实验依据。方法采用腺嘌呤灌胃制成小鼠肾阳虚模型,以小鼠血清皮质醇(Cor)、睾酮(T)和肌酐(Cr)含量以及精囊腺、睾丸的脏器指数为评价指标,比较五味子、酒五味子在复方中补肾阳作用。采用氢化可的松致小鼠肾阴虚模型,以血清中环磷酸腺苷(c AMP)、环磷酸鸟苷(c GMP)、乙酰胆碱(Ach)和肌酐(Cr)含量以及小鼠肾脏、肝脏和脾脏的脏器指数为评价指标,比较五味子、酒五味子在复方中补肾阴作用。结果含有生五味子、酒五味子的五子衍宗丸、六味丸分别对肾阳虚、肾阴虚小鼠有一定的治疗作用,可改善小鼠的激素水平,增加脏器指数。含酒五味子的五子衍宗丸、六味丸作用较好。结论五味子"入补药熟用"的传统理论具有一定的科学性,临床用于治疗肾虚时应首选酒五味子。

Objective To provide scientific proof for the research of ＂the processed Schisandra chinensis fruits is different from the raw ones＂ through comparing the difference of tonifying kidney between wuziyanzong pills or liuwei pills （contains raw Schisandra chinensis） and wuziyanzong pills or liuwei pills （contains processed Schisandra chinensis）. Methods Kidney-yang deficiency rat models induced by adenine were used, and the effects of raw and different processed shizandra berry in prescriptions on kidney-yang deficiency rats were compared with the content of serum cortisol, testosterone, creatinine, and the viscera index of seminal vesicle, testicle. Kidney-yin deficiency rat models induced by Hydrocortisone were used, and the effects of raw and different processed shizandra berry in prescriptions on kidney-yin deficiency rats were compared with the content of serum cyclic adenosine monophos- phate, Cyclic guanosine monophosphate, acetylcholine, creatinine and the viscera index of kidneygangz, liver, and spleen. Results The Wuziyanzong pills and Liuwei pills （contains raw Schisandra chinensis or processed Schisandra chinensis） had certain therapeutic effects on kidney-yang deficiency rats and kidney-yin deficiency rats, such as meliorating the hormonal condition and raising the viscera index. In terms of therapeutic effects, the prescriptions contained processed Schisandra chinensis were better. Conclusions The traditional theory of ＂the processed Schisandra Chinensis Fruits as a tonic＂ is scientific. The wine steaming shizandra berry is preferred in kidney deficiency treatment.