大鼠自发性巨大肿瘤的病理分析

Pathological observation of two huge spontaneous tumors in a Wistar and a GK rats

目的研究Wistar及GK大鼠巨大自发性肿瘤的病理特征。方法观察发生巨大自发性肿瘤的Wistar及GK大鼠的生长及生存状况,手术切除肿瘤,免疫组织化学染色研究其病理特征。结果两例巨大自发性肿瘤瘤体重分别为502 g和119 g,分别为大鼠体重的64%和24%,肿瘤表面具有完整的包膜,与正常组织边界清晰,没有发现肿瘤含有血管的蒂状结构。病理检查结果显示:确定为良性纤维瘤。结论大鼠自发性巨大肿瘤为良性纤维瘤,除瘤体过大对大鼠的活动产生影响外,对生存状况无显著影响。

Objective To study the pathological features of two huge spontaneous tumors in Wistar and GK rats.Methods Forty Wistar rats and 40 GK rats were included in this study. Among those rats,two huge spontaneous tumors were observed in a Wistar rat at 14 months of age and in a GK rat at 22 months of age. The growth and survival status of the tumor-bearing rats were recorded. The tumors were surgically removed,and their pathological features were examined using HE and immunohistochemical staining（ vimentin,CK19,α-SMA,CD31,CD34,S-100,NF 及 Ki-67）. Results Both the two tumors were completely resected by surgery without much difficulties,and both host rats survived well after the operation. The weight of the two huge tumors was 502 g and 119 g,which corresponding to 64% and 24% of the body weight of their host rats,respectively. The tumors surface had a complete capsule,with a clear boundary separating from the normal surrounding tissues, and no vascular pedicle structure was found. According to the results of immunohistochemical staining,both the two tumors were diagnosed as benign fibroma. Conclusion This type of huge spontaneous tumors is benign fibroma. Besides the impact on the activities of the rats,the tumors have no significant impact on the living conditions in the hosts.