痰瘀同治法对进展期胃癌术后患者血清VEGF水平的影响

Effect of "treating both the stagnation of phlegm and blood" on Serum VEGF in Postoperative Patients with Advanced Gastric Cancer

目的:探讨痰瘀同治法对进展期胃癌术后患者血清血管内皮生长因子(VEGF)表达的影响。方法:将符合纳入标准的进展期胃癌患者,随机分为治疗组和对照组各30例。对照组行常规辨证论治,治疗组在常规辨证论治的基础上,结合辨病治疗加入痰瘀同治方。比较两组疗效及患者血清VEGF的变化情况。结果:两组治疗后积分较治疗前均降低,差异均有统计学意义(P<0.05);治疗后KPS评分较治疗前均降低,差异均有统计学意义(P<0.05);治疗组治疗后血清VEGF较治疗前降低,差异有统计学意义(P<0.05);治疗后组间比较,差异有统计学意义(P<0.05)。结论:痰瘀同治法治疗进展期胃癌术后患者,有一定的疗效,能降低患者血清中VEGF表达水平。

Objective： To investigate the influence of treating both the stagnation of phlegm and blood on serum vascular endothelial growth factor （VEGF） in postoperative patients with advanced gastric cancer. Methods： The 60 patients with advanced gastric cancer were randomly divided into two groups. Patients in control group were treated based on syndrome differentiation. Patients in treatment group were treated with combination of treatment both the stagnation of phlegm and blood and treatment based on syndrome differentiation. The clinical symptom value in Chinese medicine, as well as KPS before and after therapy was observed, and the levels of serum VEGF were detected in two groups before and after treatment. Results： The clinical symptom scores and KPS scores decreased in both groups after treatment （P〈0.05）. The VEGF content in treatment group decreased after treatment （P〈0.05）, and the content in treatment group was lower than the control group （P〈0.05）. Conclusions： Treatment both the stagnation of phlegm and blood can significantly reduce the gastric serum levels of VEGF in advanced gastric cancer.