ICP-MS法测定血栓通注射剂中14种重金属元素含量

Determination of 14 Hazard Elements in Xueshuantong Injection(血栓通注射剂) by ICP-MS

目的：建立电感耦合等离子体质谱法测定血栓通注射剂中14种重金属元素含量的方法。方法：样品经微波消解处理后用ICP-MS进行测定,以绿茶为质控标准物质,内标法定量。结果：14种元素均呈良好的线性关系,r均大于0.998,方法检出限0.00094~0.037μg/L,加样回收率在94.1%~105.7%之间,RSD%均小于7%。结论：该方法准确简便,快速灵敏,可为中药注射剂中重金属元素的检测与控制提供参考。

Objective： To develop a method for the determination of 14 hazard dements in Xueshuantong injection （血栓通注射剂）. Methods： The samples were digested by microwaves and then to be detected by ICPMS, used with internal standard quantitative determination and Green tea as quality control material. Results： For all of the analyzed hazard elements, the correlative coefficients of the calibration curves were over 0.998, the detection limits of the method were range from 0.00094-0.037 μg/L, the average recoveries of the 14 elements were in the range of 94.1%-105.7%, the RSDs was all less than 7%. Conclusions： The method is simple, accurate and high sensitive, and it can be used for the determination of monitoring the hazard elements in TCM injection.