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三苯氧胺相关性脂肪肝中西医研究进展

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摘要 三苯氧胺作为绝经前雌激素受体阳性的乳腺癌患者的首选药物,可有效降低乳腺癌的复发率和转移率,但因需长期服用可导致包括脂肪肝在内的诸多不良反应。Nishino等报道,乳腺癌患者服用三苯氧胺后两年内脂肪肝的发生率为43.2%。
出处 《北京中医药》 2016年第5期498-501,共4页 Beijing Journal of Traditional Chinese Medicine
基金 北京市科委医学重大科技项目(D131100002213001) 北京市医管局临床技术创新项目(XM201410)
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  • 1Early Breast Cancer Trialists ' Collaborative Group (EBCTCG). Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival:an overview of the randomised trials [ J ]. Lancet, 2005,365 (9472) : 1687-1717.
  • 2Nishino M, Hayakawa K, Nakamura Y, et al. Effects of tamoxifen on hepatic fat content and the development of hepatic steatosis in patients with breast cancer: high frequency of involvement and rapid reversal after completion of tamoxifen therapy [ J ]. Am J Roentgenol, 2003,180( 1 ) :129-134.
  • 3Kotiloglu G, Aki ZS, Ozyilkan O, et al. Tamoxifen-induced cirrhotic process [ J ]. Breast J,2001,7 (6) :442-443.
  • 4Hewitt KN, Pratis K, Jones ME, et al. Estrogen replacement reverses the hepatic steatosis phenotype in the male aromatase knockout mouse [ J ]. Endocrinology, 2004,145 : 1842-1848.
  • 5Egawa T, Toda K, Nemoto Y, et al. Pitavastatin ameliorates severe hepatic steatosis in aromatase-deficient (At-/-) mice[J]. Lipids,2003,38(5) :519-523.
  • 6Lelliott C J, Lopez M, Curtis RK, et al. Transcript and metabolite analysis of the effects of tamoxifen in liver reveals inhibition of fatty acid synthesis in the presence of hepatic steatosis [ J ]. FASEB J, 2005,19 ( 9 ) : 1108-1119.
  • 7Larosche I, Letteron P, Fromenty B, et al. Tamoxifen inhibits topoisomerases, depletes mitochondrial DNA, and triggers steatosis in mouse liver [ J]. J Pharmacol Exp Ther,2007,321 ( 1 ) :526-535.
  • 8Zhao F, Xie P, Jiang JL, et al. The effect and mechanism of tamoxifen-induced hepatocyte steatosis in vitro [ J]. Int J Mol Sci,2014,15(3) :4019-4030.
  • 9Oddrun AG,Therese HR, Rolf KB. Causes and prevention of tamoxifen-induced accumulation of triacylglycerol in rat liver[ J ]. J Lipids Res ,2006,47 (10) :2223-2232.
  • 10Taishi M, Yasuyuki T, Koichi T, et al. Hepatoprotective effect of tamoxifen on steatosis and non-alcoholic steatohepatitis in mouse models [ J ]. J Toxicol Sci, 2012, 37(5) :931-942.

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