女性代谢综合征患者高尿酸血症患病率及危险因素分析

Morbidity and risk factors of hyperuricemia in female patients with menopausal syndrome

目的探讨女性代谢综合征(MS)患者高尿酸血症(HUA)的患病情况及相关危险因素。方法对619例女性MS患者进行问卷调查及实验室检查,以血尿酸(UA)<360μmol/L者为单纯MS组,UA≥360μmol/L者为MS合并HUA组,比较2组检测指标差异,采用logistic回归分析HUA危险因素。结果女性MS患者HUA患病率为12.44%;MS合并HUA组年龄、TC、TG、Cr均高于MS组,出现血脂异常、高血压的比例明显高于MS组;年龄增加(OR=2.459)、高TG(OR=1.809)、高TC(OR=1.741)、饮酒史(OR=5.389)是HUA的危险因素。结论合并HUA女性MS患者脂代谢紊乱较为严重,年龄增加、高TG、高TC、饮酒史是女性MS患者出现HUA的危险因素。

Objective To investigate the morbidity and risk factors of hyperuricemia in female patients with menopausal syndrome（ MS）. Methods Questionnaire investigation and laboratory examination were conducted,those with UA 360 μmol/L were MS group,whose with UA≥360 μmol / L were MS and HUA group,the differences of indicators between two groups were compared,logistic regression test was used to analyze the risk factors of HUA. Results The morbidity of HUA in female MS patients was 12. 44%,age,TC,TG,Cr of MS and HUA group were higher than that of MS group,the proportion of dyslipidemia and hypertension was significantly higher than that of MS group,advanced age（ OR = 2. 459）,higher TG（ OR = 1. 809）,higher TC（ OR = 1. 741）,alcohol consumption history（ OR = 5. 389） were risk factors of HUA. Conclusion Female MS patients with HUA have more serious dyslipidemia,advanced age,higher TG,higher TC and alcohol consumption history were risk factors of hyperuricemia in female patients with MS.