摘要
2型糖尿病(DM)并发的动脉粥样硬化(AS)由于具有斑块不稳定、供血区缺血严重及治疗后再狭窄率高等特点成为导致2型DM患者死亡及截肢最常见病因。对2型DM血管并发症制定并实施针对性强的治疗方案对降低此类疾病对人类健康的危害有重要意义。而2型DM背景下严重的血管病变动物模型的建立,则为研究并进一步实施2型DM血管并发症治疗方案提供了实验基础。本文首先对2型DM并发的严重的血管病变发生机制进行探讨,进一步对现阶段国内外建立此类血管病变动物模型的实验方法进行综述。
Diabetes mellitus（ DM） complicated with atherosclerosis（ AS） is the most common cause of amputation and death in patients with type 2 DM due to the instability of plaque,severe ischemia and the high rate of restenosis after treatment. It is important to reduce the diabetic vascular complications in those patients. Establishment of animal models of severe diabetic vasculopathy will provide an experimental basis for further studies on those complications. In this paper,we will firstly discuss the mechanism of the development of severe diabetic vasculopathy and then review the methods referring to the establishment of this kind of animal models worldwide.
出处
《中国实验动物学报》
CAS
CSCD
北大核心
2016年第3期327-331,共5页
Acta Laboratorium Animalis Scientia Sinica
关键词
糖尿病
血管病变
动物模型
Diabetes mellitus
Vasculopathy
Animal model
