妊娠期糖尿病患者体重对甘丙肽水平的影响

Effect of Galanin on BMI in Patients with Gestational Diabetes Mellitus

探讨妊娠期糖尿病（GDM）患者血浆甘丙肽（GAL）水平对体质量指数（BMI）和糖代谢的影响。选择我院产科2015年2月-2015年10月收治的妊娠期糖尿病患者30例作为GDM组,另纳入同期医院收治的正常孕妇30例作为对照组。统计两组受试者的BMI,糖化血红蛋白（HbA1c）,空腹血糖（FBG）,餐后2小时血糖（2hPPG）和GAL水平。GDM组BMI、HbA1c、FBG、2hPPG和GAL均分别高于对照组,差异有统计学意义（P〈0.05）;校正混杂因素后,偏相关分析表明,GDM组的GAL水平与BMI、FBG呈显著正相关（P〈0.05）,对照组中GAL与各指标均不存在相关性（P〉0.05）;多元线性分析结果表明,GDM患者GAL与BMI呈正相关。GDM患者BMI增加与GAL升高有关,应注意体重控制。

To evaluate the effect of galanin（GAL）on BMI and glucose metabolism in patients with gestational diabetes mellitus（GDM）.In February to October 2015,30 patients with gestational diabetes mellitus in our hospital were selected as GDM group,during the same period,30 patients with Normal pregnant women in our hospital were selected as control group.BMI,HbA1c,fasting blood glucose（FBG）,2h postprandial plasma glucose（2h PPG）and GAL levels in two group were compared.The levels of BMI,HbA1 c,FBG,2h PPG and GAL of GDM group were significantly higher than the control group.With adjusted other factors,levels of GAL were positively related to BMI and FBG（P〈0.05）.There were no significant correlations between GAL and the index in the control group（P〉0.05）.Multiple linear regression analysis showed that GAL was positively correlated with BMI（P〈0.05）.The level of GAL in patients with gestational diabetes mellitus was related to BMI.