黄芪桂枝五物汤抗大鼠坐骨神经痛的药效学研究

Pharmacodynamics Study in Huangqi-guizhi-wuwu Decoction Treatment of Sciatica

大部分镇痛药在很多患者身上有镇痛效果但是有严重的副作用。因此,临床上亟需找到安全有效的能够治疗神经痛的药物。采用SD大鼠,以机械性疼痛刺激试验,热敏试验和神经传导速率试验考察治疗效果。黄芪桂枝五物汤3周左右,能够有效的治疗CCI所致大鼠的神经疼痛,恢复神经传导速率。黄芪桂枝五物汤治疗损伤性神经痛具有确切疗效。

Despite being ranked as first-line drugs,opioids and non-steroidal anti-inflammatory drugs couldn＇t meet the clinical needs for treating neuropathic pain in those patients; moreover,these drugs could produce the terrible side-effects in a long-term use.The analgesic effects of the HD were respectively observed by PWD,thermal and NCV test in SD rats.Administration Huangqi-Guizhi-Wuwu decoction about three weeks,can effectively treat nerve pain caused by CCI rats,restoring nerve conduction velocity.Huangqi-guizhi-wuwu decoction treating traumatic neuralgia having the exact effect.