中国HIV感染者和艾滋病患者抗逆转录病毒治疗后耐药情况的Meta分析

Meta-analysis on drug resistance of HIV infections and AIDS patients after antiretroviral therapy in China

目的：了解中国HIV感染者和艾滋病患者抗逆转录病毒治疗后的耐药情况。方法检索中国知网、万方数据库和Pubmed数据库，将中国HIV感染者/AIDS患者抗病毒治疗后耐药性的文献纳入研究。应用R软件进行Meta分析。结果最终纳入15篇文献，经Meta分析结果显示，中国HIV感染者和艾滋病患者抗逆转录病毒治疗后总耐药率为4%；中等发达地区耐药率为4%，欠发达地区耐药率为5%；疫情较重地区的耐药率为5%，疫情居中地区为4%。结论中国HIV感染者/AIDS 患者经抗逆转录病毒治疗后总耐药率不高。

Objective To investigate the drug resistance of HIV infections and AIDS patients after antiretroviral therapy in China. Methods National Knowledge Infrastructure （CNKI）, Wangfang Database and Pubmed Database were searched for studies of drug resistance of HIV infections and AIDS patients after antiretroviral therapy in China. Meta-analysis was made by R software. Results A total of 15 studies were identified. Meta-analysis result showed that the drug resistance rate of HIV infections and AIDS patients after antiretroviral therapy was 4% in China. The drug resistance rates in middle developed regions and less developed regions were 4%and 5%, respectively. The drug resistance rates in severe epidemic regions and middle epidemic regions were 5%and 4%. Conclusions The drug resistance of HIV infections and AIDS patients after antiretroviral therapy in China is not high.