肾癌患者血清VEGF的水平及其与临床病理分期的关系

Renal Cell Carcinoma: Relationship between Level of Vascular Endothelial Growth Factor in Serum of Patients and Clinical Pathological Stage

目的:探讨肾癌患者血清血管内皮生长因子(VEGF)的水平及其与临床病理分期的关系。方法:选择2013年1月至2015年1月在我院行手术治疗的肾癌患者56例为观察组,选择同期在我院进行健康体检的正常成人50例作为对照,所有患者的诊断均经病理切片证实,对所有研究对象,采集其清晨空腹静脉血,用酶联免疫吸附法(ELISA)检测血清中的VEGF和VEGF受体-1(VEGFR-1)。结果:观察组血清中VEGF和VEGFR-1的浓度分别为(132.75±68.31)ng/mL和(33.76±15.39)ng/mL,均显著高于对照组,差异有统计学差异(均P<0.05);不同分期患者血清中VEGF和VEGFR-1浓度差异有统计学意义(均P<0.05),病理分期增加,VEGF与VEGFR-1的浓度增加,VEGF与VEGFR-1呈正相关(r=0.625,P<0.05)。结论:血清VEGF水平可用于诊断RCC,且对于预判RCC的病例分期具有重要价值。

Objective： To explore the relationship between level of vascular endothelial growth factor（VEGF） in serum of patients with renal cell carcinoma（RCC） and clinical pathological stage. Methods： A total of 56 patients with renal cell carcinoma, who underwent operation in Yunnan first people＇s Hospital from January 2013 to January 2015 were chosen as observation group; 50 cases of normal adults participated in health examination in the same period in the hospital, as control group. All the patients were confirmed by pathological biopsy. Early morning fasting venous blood of the research subjects were drawn, and the levels of VEGF and VEGFR-1 in the sera of the subjects were detected by ELISA. Results： The levels of VEGF and VEGFR-1 in the serum of patients with RCC were 132.75 ±68.31）ng/m L and（33.76±15.39）ng/m L respectively, which were significantly higher than the control group, with significant differences（P〈0.05）. There were significantly statistical difference in VEGF and VEGFR-1 concentrations in the serum of patients with different stages（P〈0.05）. VEGF was positively correlated with VEGFR-1（r=0.625, P〈0.05）. Conclusion： The level of VEGF can be used as the diagnosis of RCC, which has an important value in staging of RCC.