急性胰腺炎患者胃肠动力紊乱与胃肠激素的关系分析

Correlation of Gastrointestinal Motility Disorder and Gastrointestinal Hormone in Patients with Acute Pancreatitis

目的：探讨急性胰腺炎（AP）患者的胃肠动力紊乱与胃肠激素的关系。方法：收集2014年3月～2015年4月我院消化科收治的90例AP患者为病例组,按病情严重程度分为轻症急性胰腺炎组（MAP组,39例）、中重症急性胰腺炎组（MSAP组,33例）及重症急性胰腺炎组（SAP组,18例）,并于同期抽取30例健康体检者作为对照组,通过采用双抗体夹心酶联免疫法（ELASA）测量入院第1、3、7天的血清胃动素（MTL）、血管活性肠肽（VIP）在各组中的水平,同时测量口盲传递时间（OCTT）来衡量AP的严重程度。结果：MAP组、MSAP组及SAP组血清MTL水平均较对照组明显降低,且随着入院治疗时间的延长逐渐升高,差异均有统计学意义（P〈0.05）。MAP组、MSAP组及SAP组血清VIP水平均较对照组明显升高,且随着入院治疗时间的延长逐渐降低,差异均有统计学意义（P〈0.05）。血清MTL水平与OCTT呈负相关性（rs=-0.534、-0.629、-0.468,P〈0.05）;血清VIP水平与OCTT呈正相关性（rs=0.464、0.326、0.671,P〈0.05）。结论：胃肠动力紊乱可能与胃肠激素异常有关,表现为MTL水平降低、VIP水平升高,且其改变幅度与病情的严重程度相一致。

Objective： To explore the correlation of gastrointestinal motility disorder and gastrointestinal hormone in patients with acute pancreatitis（AP）. Methods： A total of 90 patients with AP, who were admitted to Affiliated Hospital of Yan＇an University from March 2014 to April 2015, were chosen as case group, which was divided into mild acute pancreatitis group（MAP group, 39 patients）,moderately severe acute pancreatitis group（MSAP group, 33 patients） and severe acute pancreatitis group（SAP group, 18 patients） according to the severity of the disease; and 30 healthy people who were accepted physical examination over the same period were selected as control group. The levels of serum motilin（MTL）, vasoactive intestinal peptide（VIP） 1 day, 3days, and 7 days after admission in each group were measured by the double antibody sandwich enzyme-linked immunosorbent assay（ELISA） method; meanwhile, The severity of AP was judged with the oro-cecal transit time（OCTT）. Results： The levels of serum MTL in MAP group, MSAP group and SAP group were significantly lower than those in control group, which were gradually increased along with the extended of the admission time,the differences were statistically significant（P〈0.05）. The levels of serum VIP in MAP group, MSAP group and SAP group were significantly higher than those in control group, which were gradually reduced along with the extended of the admission time, the differences were statistically significant（P〈0.05）. The level of serum MTL was negatively correlated with OCTT（rs=-0.534,-0.629,-0.468, P〈0.05）; while the level of serum VIP was positively correlated with OCTT（rs=0.464, 0.326, 0.671, P〈0.05）. Conclusion： Gastrointestinal motility disorder may be correlated with abnormal gastrointestinal hormone, performed as the reduced level of MTL and increased level of VIP, its change extent is consistent with the severity of the disease.