关于多发性硬化中浆样树突状细胞的研究进展

Advance in Plasmacytoid Dendritic Cells of Multiple Sclerosis

多发性硬化是中枢神经系统炎症性自身免疫性疾病的典型代表,以白质脱髓鞘为主要特征。浆样树突状细胞,是专职抗原提呈细胞,是固有免疫和适应性免疫的桥梁,在启动初级免疫应答和维持免疫耐受中发挥了重要作用。由于浆样树突状细胞可以产生大量的细胞因子,特别是Ⅰ型干扰素,所以它与抗炎、免疫调节联系紧密。而目前Ⅰ型干扰素(β)被认为是治疗多发性硬化的有效的免疫调节剂。本文就浆样树突状细胞的来源、特性及其在固有免疫、适应性免疫及免疫耐受中的作用机制进行系统归纳整理,并就其未来发展前景做一简单介绍,为进一步探索免疫调节新机制和寻求多发性硬化新的治疗靶点提供理论依据和基础。

Multiple sclerosis（MS） represents the prototypic inflammatory autoimmune disorder of the central nervous system and characterized by demyelination. Plasmacytoid dendritic cells（p DCs）, professional antigen-presenting cells, bridge the innate and adaptive immune system and play a unique role in initiating primary immune responses and in maintaining tolerance. Because p DCs produce large amounts of cytokines, particularly typeⅠinterferons, so it is with the anti-inflammatory, immunomodulatory closely. At present, type Ⅰinterferon（β） is considered to be the effective immunomodulator in treatment of MS. In this paper, the origin and characteristics of plasmacytoid dendritic cells and the mechanisms of actions which p DCs play in innate immunity and daptive immunity and immune tolerance are summarized, and the future development prospects are also introduced briefly, so as to provide theoretical basis and foundation for exploring the new immune regulation mechanisms and searching new therapeutic targets for multiple sclerosis.