CT三维重建技术在肺磨玻璃结节诊断中的研究进展

Progress of Three-dimensional Reconstruction Program Applied in Diagnosis of Ground-glass Opacity

三维重建技术在肺磨玻璃结节(ground-glass opacity,GGO)鉴别诊断中具有重要作用,比传统的二维CT对于相关图像参数的测量更准确,更完整。近年来国内外学者对三维重建下GGO影像学变量包括结节平均直径、体积及CT值等在非典型腺瘤样增生(atypical adenomatous hyperplasia,AAH)、原位癌(adenocarcinoma in situ,AIS)、微浸润腺癌(minimally invasive adenocarcinoma,MIA)及ⅠA期浸润性腺癌(invasive adenocarcinoma,IAC)的鉴别诊断方面的研究越来越多样化。对作为早期肺癌病灶的GGO,三维重建测量可从其体积-倍增时间、CT值的峰度和偏度、平均CT值及CT值分布的方差等参数来进行术前良恶性评估。本文针对近年来国内外对三维重建处理技术在GGO诊断中的研究予以回顾和总结,旨在对GGO临床诊治予以提示。

Three-dimensional reconstruction program has been a critical role in differential diagnosis of ground-glass opacity （GGO）, which could measure relevant image parameters more integrated and accurate than conventional two-dimensional CT scan. Recently, researches all over the world were multifarious about differential diagnosis among atypical adenomatous hyperplasia （AAH）, adenocarcinoma in situ （AIS）, minimally invasive adenocarcinoma （MIA） and stage I A invasive adenocarcinoma （IAC） by image variables of GGO based on three-dimensional process such as diameter, volume and CT number. This technology could preoperatively evaluate pathological features of GGO, which has been treated as precursor of lung adenocarcinoma recently, by measuring parameters such as volume-doubling time, kurtosis and skewness of CT value, average CT value of nodules and standard deviation of CT value within the whole GGO nodule. The present article made a retrospection and conclusion about researches of three-dimensional reconstruction program applied in diagnosis of GGO in recent years.