弥漫型胃癌治疗的挑战和思考

Challenge and thought on treatment of diffuse gastric cancer

弥漫型胃癌是胃癌Lauren病理分型的一种,其恶性程度高,易发生转移,在我国发病率呈逐年上升趋势,成为严重威胁人类健康的重要疾病类型.目前,该病治疗仍然非常困难,很难获得满意疗效,因此近年来国内外对弥漫型胃癌研究较多,其治疗效果及预后等均有所改善.本文在阅读大量相关中外文献基础上从流行病学、诊断治疗、生物学行为的变化、影响疗效及预后的因素等多个方面对弥漫型胃癌进行系统阐述,在此基础上对目前该病诊断治疗过程中存在的问题及争议进行讨论,以方便对其开展进一步研究,并对相关临床工作提供帮助.

Diffuse gastric cancer, which has a high degree of malignancy and is metastasis-prone, is a pathological type of Lauren classification. The incidence of diffuse gastric cancer shows an increasing trend in China, and it greatly threatens the human health. There have been many studies on diffuse gastric cancer, and its treatment and prognosis have been improved to some extent. In this paper, we systematically describe diffuse gastric cancer with regard to its epidemiology, diagnosis, biological behavior, and factors affecting the treatment and prognosis, and discuss problems and disputes in current diagnosis and treatment, with an aim to provide convenience for the further research and help for clinical work.