Notch-mTOR信号介导的免疫反应与能量代谢轴:中医药预防IBD复发的可能关键

Axis of immune response and energy metabolism mediated by Notch/mTOR signaling pathway: Pivotal mechanism of traditional Chinese medicine for preventing inflammatory bowel disease

炎症性肠病(inflammatory bowel disease,IBD)是世界性难治性疾病,其难治在于高复发率.中医药治疗IBD疗效高且复发率低,但作用机制不明,然Notch与mTOR信号间相互关联,且通过各种途径调控机体免疫水平和细胞能量代谢变化,并与IBD的发作密切相关,提示调控Notch-mTOR信号介导免疫与能量轴变化可能是探索中医药预防和防止IBD复发的可能突破口和有效策略.

Inflammatory bowel disease （IBD） is a kind of worldwide refractory disease with a high recurrence rate. However, traditional Chinese medicine for IBD is associated with a better therapeutic effect and a lower recurrence rate, although the mechanism is still unclear. It is known that the Notch signaling pathway interacts with mTOR and regulates the body＇s immune level and cell energy, which is closely related with morbidity of IBD. These hint that axis of immune response and energy metabolism mediated by the Notch/mTOR signaling pathway is possibly a pivotal mechanism for traditional Chinese medicine to prevent IBD.