复发性口腔溃疡口腔病毒组失调机制的研究进展

Mechanism of oral virome imbalance in recurrent aphthous ulcer

复发性口腔溃疡(recurrent aphthous ulcer,RAU)是临床最常见的口腔黏膜疾病,其病因复杂,具体发病机制仍不十分清楚.临床缺乏特异性治疗方法.随着口腔微生态学的不断发展,口腔微生物群失调作为RAU重要发病机制,逐渐受到重视.目前口腔菌群失调的研究已取得一定进展,但作为口腔微生物群落的重要成员-病毒组的研究尚欠深入.近年来随着病毒宏基因组学在医学领域的强势介入及高通量测序技术的迅猛发展,口腔病毒组学逐渐成为继细菌组之后又一个研究热点,不断取得突破性进展.

Recurrent aphthous ulcer （RAU） is the most common oral mucosal disease with complex etiology. Since its pathogenesis is still not completely clear, specific clinical treatment is lacking. With the continuous development of oral micro-ecology, oral microbial population imbalance as an important pathogenesis of RAU is gradually recognized. At present, the research of oral flora imbalance has made some progress, but as the largest member of the oral microbial community, the research of the virome is still under development. In recent years, the rapid development of macro virus genome science and high throughput sequencing technology has led to a breakthrough in oral virome.