宫颈解脲脲原体感染与先兆流产关联的队列研究

A cohort study on the correlation between Ureaplasma urealyticum infection in cervical of early pregnant women and threatened abortion

目的了解孕妇宫颈解脲脲原体感染与先兆流产是否存在因果关联。方法用荧光定量PCR对成功临床妊娠的孕妇宫颈分泌物进行检测,随访妊娠结局。应用SPSS 16.0统计软件,运用χ2检验分析解脲脲原体阳性暴露组和解脲脲原体阴性非暴露组先兆流产发生率的差异,P〈0.05为差异有统计学意义。结果解脲脲原体阳性暴露组先兆流产发生率为25.00%;解脲脲原体阴性非暴露组先兆流产发生率为26.19%,两组发生率差异无统计学意义（RR=0.95,95%CI：0.39~2.24,P=0.89]。结论孕妇早期宫颈解脲脲原体感染与先兆流产之间无关联,该结果可能受样本量小影响,需大样本研究进一步证实。

Objective To study the correlation between cervical ureaplasma urealyticum（UU）infection and threatened abortion among early pregnant women. Methods Women of four weeks pregnancies were enrolled prospectively from September 2014 to September 2015.Cervical discharge was collected and tested for uu by Real-time PCR.Chi-square test was used to analyze the incidence rate of threatened abortion of UU positive and negative women. Results The incidence rates of threatened abortion among UU positive and negative women were 25.00% and 26.19%,the difference was not statistically significant（RR=0.95,95% CI：0.39-2.24,P=0.89）. Conclusions Cervical ureaplasma urealyticum infection in the early pregnant women is not closely correlated with threatened abortion,the small sample size and low number of patients in the study may influence the study conclusion,therefore,more well designed studies with larger sample size are needed to confirm this association.