摘要
目的探讨膀胱癌组织中c-Met的表达及意义。方法选取60例膀胱癌组织病理标本(观察组)与60例正常膀胱组织病理标本(对照组),均进行c-Met表达的免疫组化实验分析。结果 c-Met在观察组中的阳性表达率为60.0%(36/60),明显高于对照组的6.7%(4/60)(P<0.05)。在60例膀胱癌组织中,c-Met在不同病理分级、临床分期与淋巴结转移组织中的阳性表达率比较差异有统计学意义(P<0.05)。结论 c-Met在膀胱癌中呈现高表达状况,能反映膀胱癌组织的病理分级、临床分期与淋巴结转移情况,具有很好的分析价值。
ObjectiveTo investigate expression and significance of c-Met in bladder cancer tissue. MethodsThere were 60 pathological samples of bladder cancer tissue （observation group） and 60 samples of normal bladder tissue （control group）. Immunohistochemistry analysis was made on all c-Met expression. ResultsThe positive expression rate of c-Met was much higher in the observation group as 60.0% （36/60） than the control group as 6.7% （4/60） （P〈0.05）. Among the 60 bladder cancer tissue cases, positive expression rates in different pathological grades, clinical stages, and lymphatic metastasis tissues had statistical significance （P〈0.05）. ConclusionHigh expression of c-Met in bladder cancer can reveal pathological grades, clinical stages, and lymphatic metastasis tissues condition. It contains high value for analysis.
出处
《中国实用医药》
2016年第14期45-47,共3页
China Practical Medicine
关键词
C-MET
膀胱癌
免疫组化
淋巴结转移
临床分期
c-Met
Bladder cancer
Immunohistochemistry
Lymphatic metastasis
Clinical stages
