中西医结合治疗早期糖尿病肾病32例

Therapy of Integrated Medicine in the Treatment of Early Diabetic Nephropathy for 32 Cases

目的观察中西医结合疗法治疗早期糖尿病肾病的临床疗效。方法选取2012年8月—2015年7月早期糖尿病肾病住院患者62例,采用随机对照原则将其分别对照组和中西医结合治疗组,其中对照组30例患者,中西医结合治疗组32例患者。2组患者均采用常规降糖治疗方案(选用二甲双胍肠缓释片降糖治疗或应用胰岛素进行降糖治疗),在此基础上对照组选用ACEI类降压药依托普利(5 mg,日1次,口服)进行治疗,治疗组选用生脉饮加减(麦冬15 g,五味子20 g,党参20 g,黄芪10 g,山药15 g,山茱萸15 g;200 ml汤剂,口服,日2次)进行治疗。疗程为30 d。治疗后观察患者临床有效率,FBG、m Alb、SCr等检测值。结果治疗后对照组总有效率为(70%);治疗组总有效率为(93.75%),2组结果比较有显著性差异,具有统计学意义(P<0.05)。FBG治疗后2组比较无显著性差异,无统计学意义(P>0.05),m Alb、SCr治疗后两组比较有显著性差异,具有统计学意义(P<0.05)。结论中西医结合治疗早期糖尿病肾病能够改善患者肾脏功能,提高临床疗效,能够减轻患者尿微量白蛋白及症状,值得在临床中推广应用。

Objective To observe the clinical effect of therapy of integrated medicine in the treatment of early diabetic nephropathy. Methods From August 2012 to July 2015, 62 cases of hospitalizedpatients with early diabetic nephropathy were randomly divided into control group of 30 cases and integrated medicine group of 32 cases. Two groups of patients were treated with conventional iaypoglycemie treatment regimen （metformin selected intestinal sustained-release tablets hypoglyeemic therapy or using insulin antidiabetic therapy） . On the basis of the above therapy, the control group used ACEI class of antihypertensive drugs by Topley （5mg, once a day, oral） , and the treatment group used modified Shengmai drink （Radix 15g, Schisandra 20g, Codonopsis 20g, Astragalus 10g, Chinese yam 15g, dogwood 15g; 200ml decoction, oral, twice daily） . Treatment was 30d. After treatment, the clinical effect, FBG, mAlb, SCr and other detection values Were observed. Results After treatment, the total effective rate of the control group was 70%, the total effective rate of the treatment group was 93.75%, and the difference was statistically significant （P 〈0.05） . There was no significant difference between treatment groups after FBG, and the differnece was not statistically significant （P〉 0.05） . The mAlb and 5Cr of the two groups after treatment had significant difference, and the difference was statistically significant （P 〈0.05） . Conelusion The therapy of integrated medicine in the treatment of early diabetic nephropathy can improve kidney function, improve clinical effect, reduce symptoms in patients with microalbuminuria, and is worth popularizing in clinical applications.