艾司西酞普兰与帕罗西汀对精神分裂症后抑郁的疗效对比研究

A comparative study of efficacy of escitalopram and paroxetine in the treatment of depression disorder after schizophrenia

目的对比艾司西酞普兰与帕罗西汀对精神分裂症后抑郁患者的临床疗效。方法纳入精神分裂症后抑郁患者80例,随机均分为2组:观察组应用艾司西酞普兰;对照组应用帕罗西汀。在用药0周、1周、2周、4周、8周以简明精神病评定量表(BPRS)及汉密尔顿抑郁量表(HAMD)评价疗效、以不良反应量表(TESS)评价不良反应。结果所有患者用药期间BPRS、HAMD评分均呈下降趋势,与用药0周相比,差异有显著性(P<0.05);2组BPRS评分对比,各时刻均无明显差异(P>0.5);观察组用药1周HAMD评分明显低于对照组,组间差异有显著性(P<0.05),其它时刻组间对比无明显差异(P>0.05);2组总不良反应发生率无明显差异(P>0.05),观察组性功能障碍发生率明显低于对照组(P<0.05)。结论艾司西酞普兰与帕罗西汀均是治疗精神分裂症后抑郁的可靠药物,但艾司西酞普兰起效更快、对性功能影响更轻。

Objective To compare the efficacy of escitalopram and paroxetinein the treatment fo depressive disorder after schzophrenia. Methods 80 cases of depression after schizophrenia were randomly divided into 2groups,the observation group was applied escitalopram,the control group was treated with paroxetine. At 0 week,1week,2 weeks,4 weeks,8 weeks of medication,efficacy was evaluated by BPRS and HAMD and adverse reaction was evaluated by TESS. Results All patients HAMD,BPRS score showed a downward trend（P〈0.05）;BPRS score comparison of two weeks,there were no significant differences at each time（P〉0.5）;HAMD score of the observation group after 1 week of administration was significantly lower than that of the control group（P〈0.05）,and there was no significant difference between groups at other time（P〉0.5）;The total incidence of adverse reaction had no significant difference（P〉 0.05）. The incidence of sexual dysfunction of the observation group was significantly lower than that of the control group（P〈0.05）.Conclusion Escitalopram and paroxetine are reliable drugs for depression disorder after schizophrenia,but escitalopram works faster,the impact on sexual function is lighter。