哌罗匹隆治疗苯丙胺类兴奋剂所致精神和行为障碍的疗效观察

The efficacy of perospirone in the treatment of amphetamine induced psychiatric and behavioral disorders

目的观察哌罗匹隆治疗苯丙胺类兴奋剂所致精神和行为障碍的疗效和不良反应。方法选取我院2014年6月~2015年6月收治的82例苯丙胺类兴奋剂所致精神和行为障碍患者,利用哌罗匹隆进行治疗,使用简明精神病量表（BP R S）和汉密尔顿焦虑量表（HAMA）评定疗效,副反应量表（TESS）评定不良反应。结果哌罗匹隆治疗4周后疗效总有效率为97.6%。治疗4周后患者的简明精神病评定量表、汉密尔顿焦虑量表评分结果均低于治疗前和治疗2周。副反应量表显示不良反应少。结论哌罗匹隆对苯丙胺类兴奋剂所致精神和行为障碍疗效明显,不良反应发生率低。

Objective To study the efficacy and safety of perospirone in the treatment of amphetamine induced psychiatric and behavioral disorders. Methods From January 2014 June to 2015 June in our hospital,82 cases of mental and behavioral disorders due to amphetamine type stimulants were selected and treated by perospirone. The Brief psychiatric scale（BPRS）and Hamilton anxiety scale（HAMA）was used to assess efficacy and the treatment emergent symptom scale（TESS）was used to assess side effects. Results The total efficiency after 4 weeks was 97.6%. BPRS score and HAMA score of treatment after 4 weeks were respectively lower than that treatment after 2 weeks. TESS showed that perospirone has few side effects. Conclusion Perospirone treat amphetamine type stimulants induced mental and behavioral disorders was effective and adverse reactions occurrence rate is low.