抽动障碍患儿实验室检查及其诊断意义的分析

The Diagnostic Significance Analysis of Tic Disorder Children's Laboratory Tests

目的:统计抽动障碍住院患儿相关实验室检查,分析其对于抽动障碍诊断与鉴别诊断的意义。方法:抽取2013年1月至2014年9月在上海交通大学医学院附属新华医院中医科住院治疗的98例抽动障碍患儿各项主要实验室检查结果进行统计分析。结果:抗"O"异常率为17.35%,与对照组比较P>0.05,铜蓝蛋白均值为0.2719±0.0477,与对照组比较P>0.05,血沉异常率为4.08%,与对照组比较,P>0.05。炎症因子均存在一定异常,异常率最高为IL-2r达14.29%,免疫球蛋白只有Ig M存在1例(1.02%),T细胞亚群各项均存在异常,其中CD4/CD8异常率达25.51%,CD3异常率为12.24%。肝肾功能、血尿常规各项异常率统计基本正常,仅仅少数存在少量异常;结论:抗"O"、血沉和铜蓝蛋白等对TD的诊断和鉴别诊断具有重要意义,同时也应该关注患儿的免疫情况。肝肾功能、血尿常规等项目的监测对选择用药具有指导意义。

Objective： To summary the data of Tic Disorder children＇s laboratory tests and analyze its diagnostic significance for tic disorder. Methods： The laboratory test data was analyzed from 98 TD patients who treated by TCM in Xin Hua Hospital Affiliated to Shanghai Jiaotong University School of Medicine. Results： Abnormal rate of ASO was 17.35 %, compared with the control group, P〉0.05.The average of ceruloplasmin was 0.2719 ±0.0477, compared with the control group, P〉0.05. Abnormal rate of ESR was 4.08 %,compared with the control group, P0.05.Inflammatory cytokines were always abnormal, the most was IL-2r with abnormal rate 14.29 %.Just 1（1.02 %） patient＇s Ig M was abnormal. T cell subsets were always abnormal, the most were CD4/CD8 with abnormal rate 25.51 %and abnormal rate of CD3 was 12.24 %. Most patients＇ hepatorenal function, blood and urine routine analysis were normal. Conclusions：The test to ASO, ESR, ceruloplasmin is significant to TD diagnosis, and the patients＇ immunization also should be focused. The results of hepatorenal function, blood and urine routine examination can give the guidance for the drug＇s use in clinic.