临床常见细菌的耐药性监测

Surveillance of drug resistance of clinical common bacteria on clinical antibiotics

目的探讨临床常见细菌对各种抗菌药物的耐药性。方法采用纸片扩散法进行药物敏感性实验;采用WHONET5软件对细菌耐药性数据进行分析。回顾性分析我院2014年临床分离细菌耐药数据。结果粪肠球菌对万古霉素、利奈唑胺和替考拉宁的耐药率分别为1.2%、1.5%、0.8%;屎肠球菌对万古霉素、利奈唑胺和替考拉宁的耐药率分别为2.3%、0.8%、0.7%;肺炎克雷伯菌的ESBLs检出率为36.5%,大肠埃希菌的ESBLs检出率高达54.7%;流感嗜血菌对阿奇霉素、氨苄西林和左氧氟沙星的耐药率分别为4.2%、35.1%、2.9%;副流感嗜血菌对阿奇霉素、氨苄西林的耐药率分别为25.6%、36.8%。结论我院近1年来监测的常见细菌耐药性与前期监测结果相似,其中不动杆菌属在碳氢霉烯类药物的耐药性较高,必须采取相应措施对流行株的传播进行严格控制,并在合理运用临床抗生素的基础上,加强耐药性监测。

Objective To explore the clinical common bacteria to all kinds of antimicrobial resistance. Methods Drug sensitivity test were performed by disc diffusion method, the bacterial drug resistance data were analysed through WHONET software.Clinical isolated bacteria resistance data in 2014 wre retrospective analysed. Results Drug resistance rate of enterococcus faecalis to vancomycin, linezolid and teicoplanin for respectively were 1.2%, 1.5% and 0.8%, respectively. Drug resistance rate of enterococcus faecium to vancomycin, linezolid and teicoplanin for respectively was 2.3%, 0.8% and 0.7%,respectively.ESBLs of klebsiella pneumonia detection rate were 36.5%. ESBLs of Escherichia coli detection rate of were 54.7%. The drug resistance rate of Haemophilus influenza to Azithromycin, Ampicillin and Levofloxacin were 4.2%, 35.1% and 2.9%,respectively. And the drug resistance rate of Haemophilus par influenza to Azithromycin, Ampicillin resistant were 25.6% and36.8%, respectively. Conclusion The common bacteria resistance monitored by our hospital for nearly 1 year is similar to the early stage of the monitoring results. The acinetobacter genera in hydrocarbon alkene drugs have higher resistance. Strictly control the spread of the pandemic strain and take corresponding measures to strengthen the drug resistance surveillance and the rational.