HHcy患者血糖、血脂水平的变化特点

Characteristics of blood glucose and blood lipid levels in patients with HHcy

目的探讨高同型半胱氨酸血症（hyperhomocysteinemia,HHcy）患者血糖、血脂水平的变化特点。方法回顾性研究武警唐山市消防支队新华医院、唐山市人民医院住院及健康体检者528例,依据同型半胱氨酸水平分为正常对照组（〈15.0μmol/L）、轻度增高组（15~30μmol/L）、中度增高组（〉30~100μmol/L）、重度增高组（〉100μmol/L）,分别测定各组血糖、血脂水平,并比较其变化特点。结果 Hcy轻度增高组、中度增高组、重度增高组与正常对照组相比,不同程度HHcy患者TC、LDL-C水平明显升高,差异有统计学意义,两两比较差异也均有统计学意义（P〈0.05）;但各组GLU、HDL-C水平差异无统计学意义（P〉0.05）。线性相关分析表明Hcy浓度变化与GLU、TG、TC、HDL-C、LDL-C、Lpa有相关性。但以是否发生HHcy为因变量,以GLU、TG、TC、HDL-C、LDL-C、Lpa为自变量进行Logistic回归分析,结果显示HHcy发生与GLU、TG、TC、HDL-C、LDL-C、Lpa相关性并无统计学意义,而是一个多因素作用的结果,单独自变量对HHcy影响不大。结论 HHcy受多因素影响,其患者中血糖、血脂水平发生改变,以血清TC、LDL-C水平改变最为明显。

Objective To investigate the changes of blood glucose and blood lipid levels in patients with hyperhomocysteinemia（HHcy）.Methods A retrospective study were performed in528 cases from hospital of armed police public security fire control team of Tangshan or from Tangshan people′s hospital.On the basis of homocysteine levels,all cases were divided into normal control group（〈15.0μmol/L）,mild increase group（15~30μmol/L）,moderate increase group（〉30~100μmol/L）and the severe increase group（〉100μmol/L）,Blood glucose and blood lipid levels were measured in each group.SPSS 19.0software were used for statistical processing.The changes of blood glucose and blood lipid levels in patients with homocysteine were compared.Results Compared with the normal control group,TC,LDL-C level in Hcy mild increase group,in moderate increase group and in the severe increase group were increased significantly.The difference was statistically significant and two two comparison of the differences also have statistical significance（P〈0.05）.But there was no significant difference in the level of GLU and HDL-C in all the groups（P〈0.05）.Linear correlation analysis showed that the change of Hcy concentration was correlated with the GLU,TG,TC,HDL-C,LDL-C.However,if Logistic regression analysis was performed by using GLU,TG,TC,HDL-C,LDL-C,Lpa as the independent variables and HHcy as the dependent variable,the results showed that the correlation between HHcy,TG,TC,HDL-C,LDL-C,Lpa,and GLU was not statistically significant,but was the result of a multi-factor action.Independent variables had little effect on HHcy.Conclusion High homocysteine levels are affected by multiple factors.The blood glucose and blood lipid levels in the patients were changed,and the changes of serum TC and LDL-C levels were the most significant.